Medications and treatments Archive

Harvard Medical School professor Dr. Eugene Braunwald, known as "the father of modern cardiology," identified five promising future trends in cardiology. They include (1) using polygenic risk scores in newborns for early prevention of heart disease; (2) the emergence of a battery of drugs to treat inflammation; (3) improvements in cardiac cell therapy for repairing damaged hearts; (4) the development of smaller, more powerful, and less expensive left ventricular assist devices; and (5) transplanting genetically modified pig hearts into humans.

Up to three in 10 people who use marijuana may be unable to stop using the drug, even when it has negative effects on their lives. A 2023 study links this problem- known as cannabis use disorder-to a higher risk of heart problems.

A nonsurgical approach for replacing a damaged aortic valve, known as transcatheter aortic valve replacement (TAVR), has become very popular in recent years. But it may not make sense for people in their 60s, who are likely to need a second valve replacement later in life. The valves used in TAVR only last about 10 years, on average. In addition, diagnosing and treating coronary artery disease may be more challenging in people who've had TAVR. Also, the surgery to replace a failed TAVR valve is more complicated than regular valve replacement surgery. So people who are likely to need least one traditional valve surgery are better off having the surgery in their 60s rather than in their 70s. A TAVR can be done the second time around.

Blood thinners don't "thin" blood; rather, they discourage blood from clotting. Candidates for anti-clotting drugs are people at high risk for dangerous blood clots, such as those with atrial fibrillation or those who have received a stent. Others who can benefit from an anti-clotting drug are people who are immobile after surgery and individuals who have had deep-vein thrombosis (clots in the veins of the legs or arms) or pulmonary embolism (clots in the lungs). A higher risk of bleeding is the main side effect, but most people can tolerate the medication.

When prostate cancer recurs after initial treatment, doctors typically treat it with hormonal therapies. But results from a large clinical trial show that a different medication (or combination of two medications) is a better approach.

Many people end up taking a long list of medications when they might be able to safely reduce the number of daily pills. Reviewing medications with their specialists and primary care doctor can help determine which drugs may be reduced or perhaps discontinued.

The FDA approved the first pill for postpartum depression in August 2023. The fast-acting drug, zuranolone (Zurzuvae), is taken for just two weeks.

Lynch syndrome is an inherited condition that predisposes people to colorectal, uterine, ovarian, and other forms of cancer. Genetic testing can pinpoint Lynch syndrome, and genetic counseling is also recommended. People with Lynch syndrome need frequent cancer screenings and should watch for symptoms. Women with Lynch syndrome are also advised to undergo risk-reducing surgery that removes the ovaries, fallopian tubes, and uterus between ages 35 and 40, unless a woman is planning another pregnancy.

Semaglutide (Ozempic, Wegovy), which mimics a natural hormone called GLP-1, has become a popular obesity drug because it promotes dramatic weight loss. New evidence suggests this drug and others like it may also curb compulsions for things other than food. The drugs may also dampen cravings for alcohol, smoking, gambling, and excessive shopping by hampering activation of the brain's reward pathways. If further research confirms preliminary findings, the demand for GLP-1 drugs is likely to increase.

Continuous positive airway pressure (CPAP) is a first-line treatment for people with obstructive sleep apnea. The CPAP keeps the airway open by pushing a forceful stream of air through a tube and into a mask worn during sleep. The air comes from a small bedside pump (an air compressor). Other forms of positive airway pressure (PAP) may be helpful for people with central sleep apnea. Doctors determine which type of PAP therapy and device someone needs. Patients select the type of PAP mask to use with the system.