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Opioids after heart surgery: A cautionary tale

Research we're watching

A recent study found that nearly one in 10 people who received opioid pain relievers following heart surgery continued to take them for three to six months — a time point when no one should still be experiencing pain from the operation.

The study included nearly 36,000 people with private health insurance who had a coronary artery bypass graft (known as CABG or bypass surgery) or a heart valve replacement between 2003 and 2016. People who were prescribed more than 40 5-mg tablets of oxycodone (Oxycontin, Roxicodone, others) or an equivalent amount of a similar drug were at a much higher risk of prolonged opioid use than people who were prescribed lower doses. Other factors that increased a person's odds of taking opioids long-term included having CABG, being female, or having a history of chronic pain or alcoholism.

Blown up in smoke: Young adults who vape at greater risk of COVID symptoms

While the majority of deaths from COVID-19 have occurred in people 65 or older, younger people who smoke or vape are at much higher risk of becoming infected — twice as likely as those in the same age group who do not use any nicotine-containing substance.

Too many pain pills after surgery: When good intentions go awry

A reasonable and well-intentioned effort to reduce and relieve pain can inadvertently lead to a potentially life-threatening addiction, but there are some surprisingly simple ways to avoid such scenarios.

Another strategy to cope with life’s dark times

News briefs

The United States is reporting increasing numbers of "deaths from despair" (suicide, drug overdose, or alcohol poisoning). Antidepressants and psychotherapy are often used to help people who are having a hard time coping with extremely difficult times and who are at risk for dying because of it. A recent Harvard study found that another strategy may also play a part in countering despair: attending religious services. The study, published online May 6, 2020, by JAMA Psychiatry, evaluated self-reported religious service attendance among 110,000 white, middle-aged men and women who were followed for about 30 years. Compared with never attending religious services, going at least once per week was associated with a much lower risk of death from despair: 68% lower for women and 37% lower for men. Researchers say that religious participation — regardless of affiliation — may serve as an antidote to despair and provide a sustained sense of hope, meaning, peace, and positive outlook. Also, faith-based organizations promote social engagement and connectedness and preach against self-injury and substance use. The study was observational and does not prove that regularly going to a religious service prevents death from despair. However, we know from other Harvard research that using religion to cope is associated with improved outcomes for people with severe psychiatric illness. Due to the pandemic, it may be difficult to attend your usual place of worship. Consider attending services via teleconference. If you attend in-person services, wear a mask and try to stay six feet away from others.

Image: © fstop123/Getty Images

Is your habit getting out of control?

Stress can raise your risk of developing a substance use disorder. Here's how to get help when you need it.

In recent months, Americans' collective stress level has risen in response to the pandemic and economic fallout. Many people are looking for ways to help themselves feel better. Unfortunately, stress can trigger a number of unhealthy coping strategies — drinking alcohol to excess, bingeing on junk food, engaging in drug use, or other harmful behaviors. If you've ever had a substance use disorder, a bout of significant stress may even put your recovery at risk.

This is likely due to the shift the human brain makes in times of trauma. Instead of focusing on long-term goals, your brain zeroes in on short-term objectives.

Brain plasticity in drug addiction: Burden and benefit

The brain’s neuroplasticity — its ability to adapt and change — makes it possible for us to learn new skills and solve complex problems, but it also makes some people more vulnerable to the consequences of substance use disorders. This same ability also makes it possible for a person to make cognitive modifications in order to change an addictive behavior.

Looking past the pandemic: Could building on our willingness to change translate to healthier lives?

The COVID-19 pandemic has shown that people are capable of changing their behavior— surprisingly fast—when the stakes are high. Can we apply that resolve to other persistent issues that affect our health and quality of life?

A tale of two epidemics: When COVID-19 and opioid addiction collide

In our inner cities, the COVID-19 pandemic comes on top of another crisis that has plagued our country for years: the opioid epidemic. The combined effects of these two events are immense, and highlight already-existing problems with our society and our health care system.

What new opioid laws mean for pain relief

Dozens of states are cracking down on the amount of opioids doctors can prescribe.


 Image: © Darwin Brandis/Getty Images

Overdoses of powerful painkillers called opioids kill more than 115 people per day in the United States. More than 42,000 people died from opioids in 2016, five times more than in 1999. The reason? Since several of these powerful painkillers became available in pill form several decades ago, doctors have been prescribing more than patients need. "It is estimated that a large part of leftover opioids are diverted to the street, either deliberately or through theft," says Dr. Edgar Ross, senior clinician at the Pain Management Center at Harvard-affiliated Brigham and Women's Hospital.

The misuse of opioids is a risk many states are no longer willing to take. The rules limit the amounts that medical professionals can prescribe for temporary (acute) pain from surgery, injury, or illness.

Recovering from addiction during a time of uncertainty and social distancing

Because the very nature of recovery support involves face-to-face interaction, whether in support group meetings or dispensing medication, it is at odds with the need for social distancing during the COVID-19 crisis, creating barriers to receiving support and maintaining recovery.

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