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What is “broken-heart syndrome?”

This reversible heart condition — which often mimics a heart attack — is being recognized with increasing frequency.


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The term "broken heart" usually conjures up the sad ending of a love affair. In fact, the death of a spouse is a commonly cited trigger for broken-heart syndrome — a temporary weakening of the heart that causes symptoms similar to a heart attack. Also known as stress cardiomyopathy, the condition usually results from severe physical or emotional stress, though sometimes there is no identifiable trigger. Although rare, it's now being recognized much more often than in the past.

"Stress cardiomyopathy was not on anyone's radar screen 25 years ago," says Patrick O'Gara, a cardiologist at Harvard-affiliated Brigham and Women's Hospital. Japanese doctors who first described the condition in the early 1990s called it takotsubo cardiomyopathy. Why? During an episode, the heart takes on an unusual shape that resembles a tako-tsubo (octopus pot), a traditional clay vessel a fisherman uses to trap an octopus.

Finding hidden risk for heart disease

These conditions are associated with a higher risk.


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Most men are familiar with the common strategies to reduce their heart disease risk: keep cholesterol in check, manage high blood pressure, follow a heart-healthy diet, and perform regular exercise. But there may be other preventive steps you can take.

"Some age-related conditions can further increase your risk without you knowing it, which is why it's important to be mindful about all aspects of your health," says Dr. Michael Gavin, a cardiologist with Harvard-affiliated Beth Israel Deaconess Medical Center. "Fortunately, once they are recognized, these other risk factors can be addressed and managed."

The head-heart connection: Mental health and heart disease

Common mental health disorders are linked to a higher risk of heart attack and stroke. Learn to spot the warning signs.


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Heart disease and mental health issues are both common. So it's not surprising that these problems often occur together. But are people with depression or anxiety more prone to developing cardiovascular disease?

Teasing out the answer to that question has proved tricky. Some factors known to contribute to a higher risk of heart disease (for example, an unhealthy diet, lack of exercise, and smoking) are also common in people with mental health issues. Now, new research that adjusts for those potentially confounding factors suggests the answer is yes.

From street drug to depression therapy

Ketamine offers a new option for people with stubborn depression that doesn't respond to other medications.


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Many people know of ketamine as a hallucinogenic and addictive street drug, which, when abused, can put people in medical peril. But today, doctors are increasingly looking to ketamine as a potentially lifesaving treatment for people with severe, treatment-resistant depression, who may be at high risk for suicide.

"Ketamine has been shown to be effective in people who have not responded to antidepressant treatment," says Dr. Cristina Cusin, an assistant professor of psychiatry at Harvard Medical School. The fast-acting treatment has shown promise — sometimes improving depressive symptoms within hours of the first intravenous treatment.

Spectator sports: How a high-stakes game may affect your heart

Research we're watching


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Stressful events — even positive ones, such as watching an exciting sporting match — can affect your heart. During World Cup soccer and the National Football League's Super Bowl, rates of heart attacks and heart rhythm problems (arrhythmias) increase, both among sports fans and within the local population. A study published online August 20 by the American Journal of Cardiology takes a closer look at this risk.

Researchers examined data from 133 people with implanted cardiac devices in St. Louis, Mo., during two 10-day periods. The first was in early September of 2011 (the control period). The second was six weeks later during the World Series, when the St. Louis Cardinals played a series of dramatic games against the Texas Rangers.

A deeper look at psoriasis

There are ways to shorten flare-ups and, in some people, prevent them from recurring.


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Psoriasis is a big star on TV drug ads, but this autoimmune skin disease is something most people try to keep well hidden.

"Psoriasis is among the most common skin conditions, affecting about 2% of the U.S. population, and while the condition doesn't affect everyone the same way, the approach to treatment and prevention is often similar," says Dr. Gideon Smith, an assistant professor of dermatology at Harvard-affiliated Massachusetts General Hospital.

Is it safe for women to drink alcohol?

Ask the doctor


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Q. The Harvard Health Letter has often said that it is generally healthy for women to have one alcoholic drink per day. Yet I hear a recent study showed no benefit. What's the truth?

A. Before answering your question, let's define "one drink": it's 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of hard liquor. And it means having one drink each day of the week, not having seven drinks on Saturday night, sleeping it off Sunday, and begging off until next Saturday night. Now, despite the recent study, we stick with what we've said, which reflects the research of outstanding nutrition scientists at Harvard and elsewhere.

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