Immune and infectious diseases Archive

Sepsis causes or contributes to an estimated 20% of all deaths worldwide. The condition begins with an infection that spreads and over activates the immune system, which releases damaging inflammatory chemicals that lead to organ failure. Any infection can trigger sepsis, but those that begin in the lungs, urinary tract, gastrointestinal tract, or skin are more likely to do so. Older people are more susceptible to sepsis. The condition may be avoided by stopping bacterial or viral infections from occurring or worsening.

Rheumatoid arthritis (RA) affects two to three times as many women as men. Scientists are uncovering RA's potential genetic and hormonal underpinnings, which point to potential reasons why women are more vulnerable. The newest treatments, called Janus kinase (JAK) inhibitors, resulted from research that has teased out delicate differences in immune system pathways. They block numerous proteins that ramp up inflammation fundamental to RA. The wide array of drug options now available for RA help doctors personalize therapies to each patient.

In October 2024, the CDC lowered the age for healthy adults to receive a pneumococcal vaccine to 50 from 65. It also recommends a second dose of the 2024-25 COVID vaccine for people 65 and older and immunocompromised people six months after their last dose.

Keeping hands clean is a simple way to protect against from colds and flu. Proper handwashing involves using plenty of soap, lukewarm water and taking at least 20 seconds to clean the back of hands, between the fingers, and around the nails.

A 2024 study suggests that men who follow active surveillance for their low-grade prostate cancer may reduce the risk of their cancer becoming more aggressive if they maintain a healthier diet, which can help reduce inflammation.

Some scientists believe that microbes might play a part in Alzheimer's disease development. They say it could be that certain viruses or bacteria that infect the brain aren't completely eradicated by the immune system, which leads to neuroinflammation and brain cell death. It could also be that microbes trigger the release of protein deposits-amyloid-beta plaques and tau tangles-which kill neurons, further increase neuroinflammation, and lead to more neuron death.

Research has shown that men can have a higher risk for heart attacks and strokes if they suffer from certain medical conditions that might seem unrelated to heart disease. These conditions include erectile dysfunction, gum disease, peripheral artery disease, and urinary tract infections. Many factors that contribute to heart disease like inflammation and fatty deposits in the arteries are involved in these other conditions.