Breast Cancer Archive

Experts say there's little evidence that low-dose aspirin therapy brings benefits, and there are some risks.

In recent years, there's been a lot of talk about the potential benefits, and risks, of a regular regimen of low-dose aspirin. While much of the discussion has centered on whether taking low-dose aspirin can head off cardiovascular disease, some of the focus has also been on breast cancer. Can regular doses of this over-the-counter pain reliever reduce your risk of this common cancer?

For a while there were hints that the evidence was leaning that way. Back in 2017, this area of research, while still inconclusive, was somewhat promising. For example, a 2017 study published in Breast Cancer Research found that among some 57,000 women, those who reported taking low-dose aspirin (81 mg) at least three times a week had a 16% lower risk of breast cancer over all and a 20% lower risk of a specific type of hormonally driven breast cancer.

News briefs

The pandemic may have you feeling reluctant to seek medical treatment. But when it comes to cancer care, even a short delay in treatment may lead to deadly outcomes, according to a review of 34 studies published online Nov. 4, 2020, by BMJ. Researchers evaluated treatment delay and survival in more than a million people who had cancer of the bladder, breast, colon, rectum, lung, cervix, or head and neck. Each four-week delay in treatment — whether surgery, radiation therapy, or medication (such as chemotherapy or immunotherapy) — was associated with an increase of 6% to 8% in the likelihood of dying during the study period. Scientists say delays of up to eight weeks and 12 weeks further increased the risk of death. For example, in women who delayed breast cancer surgery by eight weeks, there was a 17% increased death risk; women who delayed surgery by 12 weeks had a 26% increase. Keep in mind, there are lots of unavoidable reasons why cancer treatment might be delayed, such as not being strong enough to undergo procedures or scheduling issues at a treatment center. But if there isn't a good reason to delay, it's best to get treatment as soon as possible.

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Research we're watching

Treatment for women with a type of early breast cancer called ductal carcinoma in situ (DCIS) might not be doing enough to prevent deaths from the disease, says a study published online Sept. 16, 2020, by JAMA Network Open. The study sought to determine whether women diagnosed with DCIS had a higher risk of dying from breast cancer than women who did not have the disease. They looked at 144,524 women who were diagnosed with DCIS from 1994 and 2014 and then treated for the condition. Researchers compared them against women without DCIS from the general population. They found that the women with DCIS had three times the risk of dying of breast cancer in the follow-up period, which ran until December 2016, than women without DCIS. Study authors suggest ways that might identify which women with DCIS need more aggressive therapy to prevent breast cancer death.

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Overall risk is very small, and older women who used hormonal contraceptives many years ago aren't likely to have a higher risk.

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Hormonal birth control — whether it comes as pills, injections, a ring, an intrauterine device (IUD), or an implant — may raise your risk of breast cancer, according to a study published Dec. 7, 2017, in The New England Journal of Medicine.

If you're like many women who currently use one of these contraceptive methods, or if you used one for years in the past, should you be worried?

Could a closer look at your mammogram help guide efforts to prevent heart disease?

Your mammogram could offer a glimpse at more than just the health of your breasts. It may also provide important clues about your heart.

When a radiologist reads a mammogram, she or he sometimes sees little white streaks that look like lines of chalk inside the arteries of your breast. These lines are actually deposits of calcium called arterial calcifications. If you have them, it could mean that you have similar deposits in other arteries inside your body, including those that bring blood to your heart muscle — a known risk factor for heart disease.

Ask the doctors

Q. I've heard that walking could reduce my risk of breast cancer. Is this true?

A. Yes, it's true. Walking is not only a great form of exercise to help keep your heart healthy, it could potentially reduce your risk of breast cancer. One 2013 study, published in Cancer Epidemiology, Biomarkers & Prevention, found that women who walked seven hours a week — an hour a day on average — had a 14% lower chance of getting breast cancer when compared with women who walked three hours a week or less. The benefit was seen even in women who were at higher risk for breast cancer, including those who were overweight or who were taking hormone therapy. It's not clear how walking helps, but experts speculate that physical activity might help keep the body's levels of estrogen and insulin in check. Both of these hormones can fuel breast cancer, so regulating them more effectively could reduce your risk.

Breast pain after menopause can come in many forms

Menopause has come and gone. Why do I still have breast pain?

In most cases, breast pain is a by-product of reproductive life: Like breast swelling, it waxes and wanes during the menstrual cycle, and it's one of the first symptoms of pregnancy. Many women expect breast pain to go away after menopause. When it doesn't, they may fear they have breast cancer. Fortunately, breast pain is rarely a symptom of cancer, regardless of age. Still, that possibility should be considered, along with a number of noncancerous conditions that affect the breasts.