Medications and treatments Archive

Research we're watching

Hundreds of thousands of people in the United States take prescription niacin (also known as vitamin B3) as part of a regimen to prevent heart disease. But a new analysis that was published April 12 in JAMA Network Open suggests this old drug offers no benefit for most people.

The analysis included 35,760 patients from 17 clinical trials documenting the effect of niacin on at least one cardiovascular disease outcome. About half of the people were taking niacin, and the remainder received placebo, usual care, or other lipid-lowering agents. Over all, niacin was not helpful in preventing any serious heart-related events, strokes, or deaths from heart disease.

Pinpoint the cause and take steps to preserve your mobility and independence.

Muscle weakness is sneaky. It often appears gradually and makes once-simple tasks harder — like having to rock back and forth to get out of a chair or tug a few times on the car door to open it.

More than an inconvenience, muscle weakness has a domino effect on health. It slows your metabolism (how fast your body burns energy), puts more pressure on your joints, hurts your posture, throws off your balance, and limits your mobility.

Ask questions about rules, and get supplies in advance.

When it's time for an overnight or extended trip, there are lots of things to pack — your clothes, toiletries, and maybe important documents. But sometimes medicine isn't at the top of the list. "I hear about people forgetting medications at home, not bringing enough for the whole trip, or packing them in a suitcase that gets lost," says Dr. Suzanne Salamon, associate chief of gerontology at Harvard-affiliated Beth Israel Deaconess Medical Center.

Whether you're staying across town or traveling around the world, consider the following strategies to help you maintain your medication regimen.

Research we're watching

Fewer older adults are having heart attacks, and more are surviving them, according to a study published March 15 in JAMA Network Open.

Researchers analyzed data from more than 4.3 million people ages 65 and older who had suffered heart attacks over a 20-year period beginning in 1995. Back then, 20% of those included in the study died from their heart attacks. By 2014, that number had fallen to 12%.

The condition causes leg pain and fatigue that make activity difficult, but lifestyle changes can improve how you feel.

The occasional leg pain or stiffness is often not cause for concern, but if pain or fatigue develops after just a few minutes of walking or climbing stairs, it could be an early sign of peripheral artery disease (PAD).

"PAD not only interferes with an active lifestyle, but also can put you at higher risk for a heart attack and stroke," says Dr. Michael Belkin, chief of the Division of Vascular and Endovascular Surgery with Harvard-affiliated Brigham and Women's Hospital. "You can't cure PAD once it occurs, so you want to take measures to avoid it as much as possible."

Here's how to protect yourself from this growing tick-borne disease.

Summer is the ideal time to enjoy the outdoors, but while you're interacting with nature, you need to look out for ticks that carry Lyme disease, the most common tick-borne disease in the United States.

About 300,000 people are diagnosed with Lyme disease each year, according to the CDC, and new research suggests that number will rise by 20% by mid-century.

Ask the doctors

Q. I have seasonal allergies and I'm thinking about getting allergy shots to control them. But I hate shots and would prefer the sublingual treatments. Are these treatments considered equally safe and effective?

A. The short answer to your question is yes. Sublingual allergy treatments, which are small doses of allergens administered as tablets or liquid drops under the tongue, are considered safe and effective compared with allergy shots.

Research we're watching

If you're healthy and don't have a history of cardiovascular disease, daily low-dose aspirin is no longer recommended as a preventive measure, says a new guideline released by the American Heart Association and American College of Cardiology. The risks of internal bleeding and other side effects outweigh the benefits of aspirin in this group.

The new guideline, which was based on numerous recent studies, does not apply to people who have had a heart attack or stroke or who have undergone a bypass procedure. The recommendation to take low-dose aspirin therapy in this group is unchanged.

The CDC’s Guideline on Prescribing Opioids for Chronic Pain helps doctors and patients manage treatment at safe levels and avoid dependence. Any plan to taper medication dosage should be personalized to the patient’s needs.

Drug recalls don't necessarily affect every batch of a pill or potion. You'll need to do a little homework before you stop taking your medication.

We take prescription and over-the-counter medications to get better or avoid getting sick. We know drug side effects can make us feel ill. But we don't imagine that medications can contain toxic impurities. Yet, it happens. Recently, for example, dozens of prescription blood pressure pills (angiotensin-receptor blockers, or ARBs) containing trace amounts of potentially cancer-causing compounds were recalled.

Recalls happen frequently. Sometimes, the FDA finds the manufacturing process to be defective. Other times, a dangerous side effect that was initially not apparent becomes clear later. "Some medication recalls are for problems that are not very serious, but the products have to be recalled nonetheless," says Joanne Doyle Petrongolo, a pharmacist with Harvard-affiliated Massachusetts General Hospital.