Medications and treatments Archive

Vasomotor symptoms, consisting of hot flashes and night sweats, affect 80% of women during the menopause transition and beyond. In May 2023, the FDA approved fezolinetant (Veozah) as the first nonhormonal medication designed specifically for vasomotor symptoms. Other medications deemed effective for hot flashes are prescribed off-label. They include selective serotonin reuptake inhibitors, oxybutynin, and gabapentin. But these drugs may lead to troublesome side effects. Women interested in hot flash relief should ask their clinicians for options that take into account their other symptoms.

A newer class of medications used to treat type 2 diabetes called glucagon-like peptide-1 (GLP-1) receptor agonists has gained attention because of their impressive weight-loss results—in many cases, 10% to 20% of a person's body weight. Versions of two of these GLP-1 receptor agonists, liraglutide (Saxenda) and semaglutide (Wegovy), are FDA-approved for weight loss, even for people without diabetes. However, there isn't enough evidence to know whether these drugs might be beneficial or dangerous for people who are not diagnosed with diabetes or obesity.

Contrary to its reputation as an anti-aging supplement, human growth hormone is not effective at turning back the clock, and it may carry health risks. Commitment to a healthy diet and regular exercise is still the best formula for healthy aging.

A 2023 study suggests that women who have used menopausal hormone therapy are significantly more likely to develop gastroesophageal reflux disease (GERD).

Men often confront obstacles that keep them from managing heart disease or lowering their risk for it. Harvard cardiologists share the advice they give patients who face challenges in the areas of weight loss, medication management, exercise, and diet. These include thinking about their future health goals, monitoring blood pressure, scheduling workouts, joining group weight-loss groups, and learning portion control for meals.

A 2023 study suggests taking testosterone replacement therapy does not raise the risk for heart attacks or stroke among men with cardiovascular disease or a high risk for it, but it could increase the risk of atrial fibrillation, acute kidney injury, and pulmonary embolism.

The age-related drop in sex hormone levels can cause undesirable symptoms such as hot flashes or a flagging sex drive. Various formulations of estrogen or testosterone can ease those symptoms, but hormone therapy has a mixed record when it comes to cardiovascular safety. A 2023 study suggests that testosterone therapy is safe for men at high risk for heart disease. But women at high risk for heart disease But women at high risk for heart disease considering estrogen-based therapy need to balance menopausal symptom severity versus the greater chance of an adverse cardiovascular problem.

Older people who take low-dose aspirin every day may be more likely to develop anemia. Aspirin discourages blood clots, but the drug also blocks substances that help maintain and protect the delicate tissue lining the gastrointestinal tract. Long-term aspirin use can damage this protective layer, making bleeding more likely. Minor bleeding can go unrecognized and contribute to anemia, a condition marked by a reduced number of healthy red blood cells. People currently taking aspirin should check with their doctor to see if the practice still makes sense for them.

The reason for weight gain isn't always as obvious as inactivity or a poor diet. Weight gain can stem from many other causes. For example, it might reflect age-related physiological changes such as muscle loss, poor sleep, or changes in sex hormone levels; underlying conditions such as diabetes or sleep apnea; side effects from taking certain medications, such as antidepressants or beta blockers; or possibly the effects of eating late at night or the makeup of gut bacteria. Recent or excessive weight gain warrants a visit to a doctor to help pinpoint the issue.

A nasal spray containing the experimental drug etripamil can quickly treat an abnormally fast heart rhythm called supraventricular tachycardia. The disordered rhythm occurs sporadically and can raise heart rate to as much as 200 beats per minute.