Diabetes Archive

Research we're watching

Could a single blood test one day enable doctors to diagnose Alzheimer's disease? Researchers writing in the March 2 issue of Nature Medicine say they've made advances in this area. The blood test they developed measures the concentration of pTau181 — a form of the tau protein associated with brain changes in Alzheimer's disease — in the body's blood plasma. They used the test on samples collected from more than 400 people who were part of an ongoing -memory study.

The researchers found that the blood test was able to accurately detect which patients had Alzheimer's, which were healthy, and which had a different type of dementia caused by a neurodegenerative disease. Today, doctors typically diagnose Alzheimer's using a series of tests designed to rule out other causes, but the process is time-consuming and costly. The researchers are now aiming to refine the test further, in hopes that it will someday make it easier to detect Alzheimer's at an early stage, when the disease may be easier to treat.

New information may affect your approach to treatment.

Millions of people turn to prescription and over-the-counter medications to cope with heartburn from gastroesophageal reflux disease or other stomach conditions. But navigating the risks of heartburn remedies can leave a sour taste in your mouth, since some have been tied to health concerns. Here's what you need to know about two mainstays of treatment, and how the latest developments may affect you.

H2 blockers

Histamine₂-receptor antagonists, better known as H2 blockers — such as famotidine (Pepcid) and cimetidine (Tagamet) — are available over the counter or by prescription. They block a chemical that signals the stomach to produce acid, and are the go-to drugs when an antacid like calcium carbonate (Tums) or aluminum hydroxide (Maalox) isn't strong enough.

On call

Q. When should I worry about changes in the color of my urine? What color is considered healthy?

A. If a person is well hydrated, the normal color of urine is a pale yellow. Someone who drinks large amounts of fluid or takes diuretics (water pills) can have almost clear-looking urine. A dark yellow color may indicate a need to increase your fluid intake.

News briefs

Struggling with high blood sugar or diabetes? A study published online March 6, 2020, by PLOS Medicine suggests that increasing your daily fiber intake may help. British researchers combed through dozens of studies with about 10,000 participants who had prediabetes, gestational diabetes, type 1 diabetes, or type 2 diabetes. Compared with people who ate low-fiber diets (19 grams of fiber per day), people who ate another 16 grams of fiber per day (a total of 35 grams per day) weighed less and had lower levels of blood sugar, cholesterol, and inflammation. There were also 14 fewer deaths per 1,000 people among those who ate high-fiber diets. If you'd like to increase your fiber intake, try to eat more fiber-rich foods at each meal. Good sources include whole-grain cereals, legumes, and nuts. For example, a cup of bran cereal has up to 47 grams of fiber, depending on the brand; half a cup of white beans has about 10 grams of fiber; and an ounce of almonds has about 13 grams of fiber. Increase fiber intake slowly, to give your digestive tract time to adjust, and remember to increase your water intake as well.

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News briefs

The guidelines are changing when it comes to screening for hepatitis C, a silent viral infection that attacks the liver and can cause cirrhosis, liver cancer, or liver failure. Back in 2012, the CDC recommended a one-time hepatitis C screening for the so-called baby boomer generation (anyone born between 1945 and 1965), a group that made up about 75% of all hepatitis C cases at that time. The following year, the U.S. Preventive Services Task Force (USPSTF) agreed. Now the USPSTF is expanding the screening age to all adults ages 18 to 79. The move is meant to identify more people in early stages of infection and comes as hepatitis C cases have increased almost fourfold since 2010. The USPSTF also advises screening for people outside of the recommended age range if they have ever used injected drugs. The recommendations were published online March 2, 2020, by JAMA. The CDC is in the process of developing similar recommendations. The screening requires only a simple blood test.

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What does that skin spot or growth mean, and when should you have it checked?

Even if you're diligent about sun protection (and you should be), you can still develop skin spots, growths, or other abnormalities.

But are they always cause for concern, or just a normal part of aging skin?

In the journals

Bleeding is a common side effect of anticoagulants (blood thinners). However, people with atrial fibrillation (afib) who take the drug for stroke prevention should not ignore any bleeding from their lower gastrointestinal (GI) tract, as it may signal colon cancer. That study finding was published online Feb. 7, 2020, by the European Heart Journal.

Researchers analyzed 125,418 patients who took anticoagulants for afib. Only 2,576 had lower GI bleeding during the first six months of treatment, regardless of age. Yet those who did experience bleeding had 10 times the risk of being diagnosed with colon cancer during the subsequent year compared with those who hadn't had any bleeding.

Previously thought to affect mainly children, celiac disease is now understood to be a systemic disorder that can develop at any age. A recent study found a small but significant risk of increased mortality in those with CD, but managing the condition through proper diet and medical care can mitigate the risk.

If you wear glasses or contacts, chances are you've been at least a little bit tempted to investigate the infomercials and books promoting eye exercises to improve your eyesight without surgery. Some programs even claim that faithful adherents may be able to give up their glasses. If this sounds too good to be true, that's because it is.

Purveyors of self-directed eye exercise programs have not conducted randomized trials to verify the effectiveness of their programs, and there is no medical evidence for their oft-stated claim that wearing lenses weakens the eyes and necessitates ever-stronger prescription eyewear. Furthermore, some programs are based on ideas that don't quite square with the anatomy and physiology of vision.

Research we're watching

If a woman has gestational diabetes during her pregnancy, she has a higher risk of developing diabetes later. But a study published February 10 in Diabetes Care found that breastfeeding may help reduce that risk.

The study, which used data from the Nurses' Health Study II, found that the longer a woman nursed her infant, the lower her risk of developing diabetes later in life. The study included more than 4,000 women who had gestational diabetes. Of those women, more than 800 developed diabetes within the next 25 years. Those who breastfed for six to 12 months were 9% less likely to develop diabetes, compared with women who didn't breastfeed at all. Women who breastfed for one to two years had a 15% lower risk of developing diabetes, compared with women who didn't breastfeed. And diabetes risk was 27% lower in women who breastfed for more than two years. This provides another reason that doctors may want to encourage women with gestational diabetes to breastfeed whenever possible.