Brain health Archive

Research we're watching

Scientists are getting some bright ideas on how to protect people from brain damage related to stroke by looking at the brains of hibernating squirrels.

When squirrels hibernate, blood flow to their brain slows dramatically — similar to the reduced blood flow to a human brain that occurs with an ischemic stroke (one caused by a blocked blood vessel in the brain). But unlike the nearly 800,000 people who experience ischemic strokes each year, the hibernating squirrels don't suffer any harmful consequences from this reduction in blood flow to the brain. Scientists say this difference reflects cellular changes in the squirrel brains that protect them from damage. The scientists for the NIH-funded study, who published the results in the Federation of American Societies for Experimental Biology's FASEB Journal, say they have found a potential drug that might mimic this protective hibernation process and could, one day, protect human brains from stroke-related damage.

Identifying and treating a stroke as quickly as possible can save brain cells, function, and lives. Everyone should know the warning signs of a stroke and when to get help fast.

The warning signs of a stroke can begin anywhere from a few minutes to days before a stroke actually occurs. The National Stroke Association has devised the FAST checklist to help determine whether a person is having a stroke.

News briefs

You've probably heard about tests to measure chemicals in the blood that indicate chronic inflammation in the body. They are sometimes used to estimate risk for heart disease. But what about using these kinds of biomarkers to gauge your risk for declining brain health? A study published Nov. 1, 2017, in Neurology found that having certain inflammatory markers in midlife was associated with brain shrinkage and poor memory in older age.

Researchers measured five inflammation biomarkers in about 1,600 middle-aged people and gave them brain scans and a memory test about 25 years later. Compared with people with no elevated inflammation markers, people with high levels of three or more biomarkers scored lower on the memory test and had about 5% shrinkage in the hippocampus and other parts of the brain associated with Alzheimer's disease.

Research we're watching

Among people who have atrial fibrillation (afib), those who take anti-clotting medications may be less likely to develop dementia later in life than those who don't take the drugs, a new study finds.

Afib, a disorder marked by a rapid, irregular heartbeat, raises the risk of stroke as well as dementia. Anti-clotting drugs are known to lower the risk of stroke, but the drugs' effects on dementia weren't clear. So Swedish researchers examined hospital and pharmacy registry data from nearly half a million people who were diagnosed with afib between 2006 and 2014.

In the journals

 Image: © Purestock/Thinkstock

If you have persistent trouble detecting or identifying odors, that may be an early sign of dementia, according to a study in the Sept. 25, 2017, Journal of the American Geriatrics Society. Almost 3,000 older adults, ages 57 to 85, who did not have dementia were asked to detect and identify five common odors like peppermint, fish, orange, rose, and leather. Five years later, the researchers found that almost half of those who performed poorly on the smell test (were either unable to detect the odors or unable to identify what the smells were) had been diagnosed with dementia. In comparison, 79% of those who scored high on the smell test did not have dementia.

The results only show an association between poor sense of smell and dementia, but the researchers noted that a smell test could be a simple way to identify high-risk people. It isn't clear how sense of smell and dementia may be linked, but the researchers speculated that underlying causes of dementia, like amyloid plaque buildup and tau tangles in the brain, also may affect the olfactory (sense of smell) system.

Sufferers now have more options than ever to ease the pain or even ward off attacks.

 Image: © YakobchukOlena/Thinkstock

If you've ever experienced a migraine, you know it's no ordinary headache. Not only does it cause throbbing pain, typically on one side of your head, but it may also cause vision changes, sensitivity to light, and nausea. It's the type of headache that makes you want to retreat to a dark, quiet room and stay there until it goes away. Recovering from a migraine can take time; the headache can last for hours or days. Migraines affect an estimated 28 million women in the United States, according to the American Migraine Foundation (AMF).

The World Health Organization says that migraine headaches rank in the top 10 of disabling conditions. These headaches result in lost work days, lost productivity, and high health care costs. And of course, they can cause you to miss out on pleasurable activities and time with family.

Despite the fact that headaches are extremely common, doctors don't fully understand exactly why or even how they occur. Neither the skull nor the brain is sensitive to pain, but both are surrounded by pain-sensitive membranes. Most headache pain stems from abnormalities in these membranes or nearby muscles, blood vessels, or nerves—either alone or in combination.

Women are twice as likely as men to experience moderate and severe headaches and more likely to experience certain types of headaches, such as migraine. A major reason is fluctuating hormone levels that are part of the monthly menstrual cycle.

MCI can be tough to identify, but there may be ways to postpone, and possibly prevent, its impact on memory and thinking.

Everyone has the occasional bout of forgetfulness, whether it's misplacing your keys or blanking out on a name. But if these episodes become frequent or interfere with daily life, you may have mild cognitive impairment, or MCI.

MCI falls somewhere between the usual cognitive decline of normal aging and the more serious signs of dementia and Alzheimer's disease. An estimated 10% to 20% of adults older than 65 have MCI, according to the Alzheimer's Association. But this gray area of brain health is often difficult to detect.