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Chronic inflammation in midlife linked to brain decline later

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You've probably heard about tests to measure chemicals in the blood that indicate chronic inflammation in the body. They are sometimes used to estimate risk for heart disease. But what about using these kinds of biomarkers to gauge your risk for declining brain health? A study published Nov. 1, 2017, in Neurology found that having certain inflammatory markers in midlife was associated with brain shrinkage and poor memory in older age.

Researchers measured five inflammation biomarkers in about 1,600 middle-aged people and gave them brain scans and a memory test about 25 years later. Compared with people with no elevated inflammation markers, people with high levels of three or more biomarkers scored lower on the memory test and had about 5% shrinkage in the hippocampus and other parts of the brain associated with Alzheimer's disease.

When worry becomes a problem

Feeling afraid about life issues is common as you age, but if it takes over your life, you may have generalized anxiety disorder (GAD).


 Image: © pixelheadphoto/Thinkstock

Everyone feels afraid or worried at times, but if these feelings begin to take over your life, then you may have crossed over into generalized anxiety disorder (GAD), which is the most common anxiety disorder among older adults, according to the Anxiety and Depression Association of America (ADAA).

"The issue with many older men is they often just endure the discomfort of GAD, or think it's normal, and do not talk about the problem," says Dr. David Mischoulon, director of the Depression Clinical and Research Program at -Harvard-affiliated Massachusetts General Hospital. "However, left alone to manifest, GAD may lead to serious health problems, such as high blood pressure, depression, and addictive behavior like excessive drinking."

Trouble identifying odors may be an early sign of dementia

In the journals


 Image: © Purestock/Thinkstock

If you have persistent trouble detecting or identifying odors, that may be an early sign of dementia, according to a study in the Sept. 25, 2017, Journal of the American Geriatrics Society. Almost 3,000 older adults, ages 57 to 85, who did not have dementia were asked to detect and identify five common odors like peppermint, fish, orange, rose, and leather. Five years later, the researchers found that almost half of those who performed poorly on the smell test (were either unable to detect the odors or unable to identify what the smells were) had been diagnosed with dementia. In comparison, 79% of those who scored high on the smell test did not have dementia.

The results only show an association between poor sense of smell and dementia, but the researchers noted that a smell test could be a simple way to identify high-risk people. It isn't clear how sense of smell and dementia may be linked, but the researchers speculated that underlying causes of dementia, like amyloid plaque buildup and tau tangles in the brain, also may affect the olfactory (sense of smell) system.

Exercise is an effective stress-buster

If exercise were available as a pill, experts say, everyone would be taking it. One reason is that exercise is very good at defusing stress. If you exercise — especially right when the stress response is triggered — you burn off stress hormones just as nature intended, instead of letting them pile up.

What's more, just about any form of motion on a regular basis helps relieve pent-up tension. Rhythmic, repetitive movements, such as walking, running, swimming, bicycling, and rowing — and specific types of exercise such as yoga, tai chi, and qigong — actually elicit the relaxation response, too. Regularly engaging in these kinds of activities can help you ward off everyday stress.

Navigating the holidays in recovery

While the holiday season is a time of festivities and reconnecting with family, for people in recovery from substance use disorders, these specific situations and events can be especially stressful. For them it’s crucial to plan ahead and to make sure recovery remains the priority at all times.

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