Medical Tests & Procedures Archive

A polygenic risk score for heart disease is based on an analysis of more than three million common DNA variants and is expressed as a percentile. People can have zero, one, or two copies of any variant, each of which may either raise or lower the risk of coronary artery disease. Many of these variants occur in genes known to affect heart disease, such as those related to cholesterol, blood pressure, and blood clotting. Others aren't well understood and may provide targets for future research, potentially fueling new drug discovery efforts. For now, the potential benefits of this test are greatest for people under 50.

Prostate-specific antigen (PSA) screening can help identify early prostate cancer, but it also can lead men to have biopsies and invasive treatments they may not need. This complexity has caused the medical community to re-evaluate how best to use PSA testing. More doctors are using PSA screening in ways that minimize the use of biopsies, such as by following a worrisome test result with MRI of the prostate. If a man does have a biopsy and a cancer is found, PSA testing can help the man follow active surveillance.

If people see evidence of plaque buildup inside their arteries, it may motivate them to take better care of their heart health, according to a 2023 study.

The thyroid gland releases hormones that affect the heart. Too little thyroid hormone slows the heart rate and may boost blood pressure and cholesterol levels, while too much can trigger abnormal heart rhythms and high blood pressure.

Many chronic conditions seem to be related. Examples include obesity, high blood pressure, type 2 diabetes, high cholesterol, and heart disease; hearing loss and dementia; obstructive sleep apnea and high blood pressure; various autoimmune diseases; and obesity and joint problems. People with chronic conditions should ask their doctors about the risk for associated diseases.In some cases, they should have certain health screenings to check for them. In other cases, additional screening isn't automatic.

Wearing a device that automatically records blood pressure every 30 to 60 minutes for 24 hours (known as ambulatory blood pressure monitoring) may better predict death from cardiovascular disease and other causes than clinic blood pressure readings.

Melanoma kills about 8,000 Americans each year. Most people are at low risk of melanoma and don't need annual skin cancer screenings. People should be screened each year if they have risk factors such as dozens of atypical moles, a family history of melanoma or atypical moles, an earlier skin cancer, certain genetic mutations or predisposition, immune-suppressing therapy after organ transplantation or for inflammatory bowel disease, a history of blistering sunburns, or substantial tanning bed use.