Medical Tests & Procedures Archive

Leg pain may be caused by deep-vein thrombosis (DVT), a blood clot that forms in a deep vein, usually in the leg. Left untreated, the clot may break off, travel to the lungs, and cause blockage in a lung artery, known as pulmonary embolism (PE), which can be life threatening. Diagnosis of DVT and PE may include a review of symptoms, a D-dimer blood test, a leg ultrasound, or a chest CT scan. Both conditions are most often treated with direct-acting oral anticoagulants.

After a heart attack or stent placement, people typically take a combination of aspirin and another antiplatelet drug. After one year, the new standard practice is to stop the aspirin, in contrast to the previous practice of stopping the other drug.

High levels of Lp(a)-a fatty particle similar to LDL cholesterol-may double or triple a person's risk of a heart attack. About one in five adults may have elevated levels, which also raises the risk of stroke and aortic stenosis. Unlike LDL, which rises with age and is influenced by diet and exercise, Lp(a) remains largely constant over a person's lifetime, so a one-time test suffices for screening. Lp(a) testing is becoming more common now that five promising new Lp(a) therapies are in development.

Roughly one in six men will be diagnosed with prostate cancer at some point in their lives, but these cancers usually aren't life-threatening. The least risky form of the disease occurs frequently with age, will not metastasize to other parts of the body, and it doesn't require any immediate treatment. So, should it even be called cancer?

Researchers are developing tools for predicting how fast prostate cancer might progress; among the most promising are those that count circulating tumor cells (CTCs) in blood samples. Research shows that high CTC counts predict poorer survival and faster disease progression. But they are also predictive for early-stage metastatic prostate cancer that still responds to hormonal therapy.

In a 2024 study, transperineal prostate biopsies were less likely to cause infections than traditional transrectal biopsies. Transperineal biopsies retrieve tissue samples using a thin needle inserted through the skin between the scrotum and rectum.

Pap tests, the mainstay screening method to detect cervical cancer, are uncomfortable for some women. In mid-2024, the FDA approved a new self-swab test that can detect human papillomavirus, which causes most cases of cervical cancer. The self-swab test collects cells from the vaginal wall instead of the cervix. Clinicians guide women on how to perform the test in a doctor's office. The self-swab method offers women several benefits, including comfort, accuracy, and potentially greater access to screening.

Abnormal results on a prostate-specific antigen (PSA) screening test for cancer are typically followed by a systematic biopsy. But systematic biopsies can be problematic, and researchers are seeking alternatives. A large European study provides encouraging evidence favoring a different approach that uses MRI instead of biopsy.

Updated guidelines say adults don't need routine testing of vitamin D levels. However, they should aim for daily vitamin D intake of 600 international units (IU) until age 70, and 800 IU after that either through vitamin D-fortified foods or a supplement of up to 1,000 IU.

Men with high prostate-specific antigen (PSA) levels often get a biopsy of prostate tissue to check for cancer. The results of the biopsy are calculated to create a Gleason score, which helps doctors assess whether the cancer is low-, medium-, or high-risk. Based on that information, doctors may recommend that a man follow active surveillance (in which he monitors his PSA for changes) or begin cancer treatment.