Cholesterol and lipids Archive

In July 2026, the FDA approved enlicitide (Lipfendra), a pill that lowers harmful LDL cholesterol by nearly 60%. It is the first pill version of a class of injectable LDL-lowering drugs known as PCSK9 inhibitors.

People who have a low coronary artery calcium score (between 1 and 99) have signs of early heart disease. Current guidelines recommend taking a statin, with a goal of lowering LDL cholesterol by at least 30%.

People who maintain or improve their heart-related risks over time are less likely to develop calcification of the aortic valve, which may lead to aortic stenosis.

Five numbers give a thumbnail assessment of overall heart health and what factors people might need to address to lower the risk of a heart attack or stroke. These numbers offer ideal goals for most people, although targets vary for individuals based on age or other health conditions.

For many people, non-HDL cholesterol (which is total cholesterol minus HDL cholesterol) may be as good as (or even more reliable than) LDL for assessing a person's risk of heart problems.

Statin dosages fall into three categories (low, moderate, or high) based on how much the medication can lower LDL. The choice of a statin depends on a person's risk.

Learn to manage your triglyceride levels to avoid having a higher risk of heart disease and stroke.

Making plaque disappear is not possible, but it is possible to shrink and stabilize it. Drugs called statins can help with this, and so can eating a heart-healthy diet, exercising, and quitting smoking.

The 2026 lipid guidelines explain how people can estimate and lower their risk of a heart attack. They include information about tools and tests, updated targets for LDL (bad) cholesterol, and advice about lifestyle changes and medications.

The scientific understanding of HDL cholesterol has evolved in recent years, and many cardiologists now believe that HDL may be more of a bystander rather than a "good guy" that helps lower heart disease risk. While some types of HDL are great at plucking excess cholesterol from LDL and artery walls (a process referred to as reverse cholesterol transport) other types of HDL don't do this. In clinical trials, medications to raise HDL levels-including a drug specifically designed to improve reverse cholesterol transport-have not succeeded in lowering heart attacks and strokes.