Cholesterol and lipids Archive

In people with obesity, a high-dose weekly injection of the diabetes drug semaglutide caused a 15% weight loss and improved other heart-related risk factors. Semaglutide works by mimicking a substance called GLP-1, which is made naturally by the gut and the brain. It prods the pancreas to release insulin when blood sugar rises too high, reduces appetite, and makes people feel full following a meal.

For decades, high intake of fat was thought to cause weight gain, heart disease, and maybe even cancer. The solution? Go low-fat, which often meant consuming more carbs and more sugar. But nutritionists now suggest people actually need adequate amounts of "good" unsaturated fat, and less "bad" saturated fat, for optimal health. Following popular heart-healthy diets, like the Mediterranean and MIND diets, and making simple dietary changes can help people get adequate amounts of good fats.

A coronary artery calcium scan (often called a calcium scan) uses a special type of CT scan to look for calcium deposits in the lining of the heart's arteries. The results can help people decide whether to start taking a statin.

A gene editing technique that permanently shuts down a cholesterol-raising protein called PCSK9 is being tested in heart attack survivors with an inherited form of high cholesterol. The one-time infusion contains tiny particles that contain the editing tools, which travel through the blood to the liver and changes the cells that produce the protein. If early data show the treatment to be safe and effective, the therapy potentially could be used in people who have "garden variety" high cholesterol.

Coffee drinking has been linked to a lower risk of dying of heart disease. Coffee contains potent anti-inflammatory substances called polyphenols that may improve blood sugar control and help blood vessels contract and relax. Although the caffeine in coffee may help people control their weight, it can trigger a short-term rise in blood pressure and heart rate. Filtered coffee, which removes substances that may raise LDL (bad) cholesterol, appears to be a better option than unfiltered coffee.

Nuts contain healthy unsaturated fats, protein, and important nutrients like potassium, and there is ample evidence that eating nuts regularly helps protect against heart disease.

Doctors concentrate on helping men lower their blood levels of low-density lipoprotein (LDL), or "bad" cholesterol, to lower their risk of cardiovascular disease. Lower HDL levels are associated with higher cardiovascular risk. This may be related to HDL's role in helping to remove excess cholesterol in arteries that can lead to plaque buildup and increase the risk of heart attacks and strokes. However, no specific therapies to raise HDL levels have improved outcomes.

A 2022 study found that a statin drug lowers LDL cholesterol better than six popular dietary supplements. While not everyone with high LDL needs a statin, these drugs are proven to lower heart attack risk in people who have or are at high risk of heart disease based on a common risk calculator. Dietary supplements such as cinnamon, garlic, and turmeric aren't helpful for addressing heart-related risks, and product labels often offer false promises regarding cardiovascular benefits.

Most adults need seven to nine hours of sleep each night, but more than one-third consistently sleep fewer than seven. Reasons for poor sleep include pregnancy, menopausal night sweats, medication use, sleep disorders, and various illnesses. Sleep deprivation can raise the risks for such conditions as diabetes, certain cancers, obesity, dementia, depression, and heart disease. To promote sounder sleep, people can keep consistent sleep-wake schedules, reduce intake of caffeine and alcohol, and avoid using electronic devices before bed.

About 20% of people have high blood levels of lipoprotein(a)—Lp(a) for short—a fatty particle that's like the evil twin of the more familiar LDL ("bad") cholesterol. Elevated Lp(a) which can double or triple risk of a heart attack and raise stroke risk, and is linked to problems with the heart's aortic valve. With new treatments that can lower Lp(a) on the horizon, cardiologists are now testing more people for this biomarker, which is not included in standard cholesterol tests.