Alzheimer's Archive

A 2023 study suggests that people who average 10 or more hours sitting each day face higher risks of dementia than those who sit less, and those risks persist even if they exercise.

For the first time, consumers can order a blood screening for Alzheimer's disease. The screening looks for two types of brain proteins, one of which is associated with Alzheimer's. Doctors have concerns about the screening: it's not FDA-approved, there's little information about its accuracy, and it can take a few days to speak with a doctor about the results. By comparison, an official Alzheimer's diagnosis involves a comprehensive evaluation of someone's current and past health problems, physical and neurological exams, family history, blood tests to rule out hidden conditions that might be causing memory problems (such as vitamin B₁₂ deficiency), and imaging tests.

A 2023 study of lab animals suggests that the population of microbes in an individual's gut may influence the risk of developing Alzheimer's disease. Researchers found that healthy lab rats developed signs characteristic of Alzheimer's disease when they were injected with gut microbe samples from people with Alzheimer's. Rats that received samples from the most severely affected Alzheimer's patients developed the greatest brain abnormalities and memory problems. Rats did not develop these problems when they were injected with samples from people who had no signs of the disease.

An estimated 3% of adults ages 65 and older currently have dementia, and that proportion rises substantially as people age. The most convincing evidence for reducing one's risk relates to the basic foundations for an overall healthy lifestyle: aerobic exercise, a plant-based diet, and quality sleep. Aerobic exercise helps reduce the buildup of toxic proteins in the brain and improves blood flow, a plant-based diet can manage inflammation, and quality sleep helps the brain clear out harmful proteins.

The CDC estimates that 3.3 million Americans have myalgic encephalitis/chronic fatigue syndrome, a tricky-to-diagnose illness. Here we share one story about living with that illness from the Health Story Collaborative, which helps people delve into the healing power of narrative.

Older adults who take medications to lower their blood pressure may reduce their risk of dementia, according to a 2023 study. The finding reinforces the connection between heart and brain health.

Seasonal affective disorder (SAD), a type of depression that begins in late fall and early winter, is caused by lack of sunlight exposure. Common symptoms of SAD include lack of sexual energy, overeating, problems sleeping, and social withdrawal. SAD is also associated with impaired cognitive function. Getting more sunlight from being outdoors or sitting in front of a sunlit window helps stimulate the brain's 24-hour sleep-wake clock. Taking antidepressants and using light therapy (which involves sitting in front of a light box) also can help manage SAD.

Semaglutide (Ozempic, Wegovy), which mimics a natural hormone called GLP-1, has become a popular obesity drug because it promotes dramatic weight loss. New evidence suggests this drug and others like it may also curb compulsions for things other than food. The drugs may also dampen cravings for alcohol, smoking, gambling, and excessive shopping by hampering activation of the brain's reward pathways. If further research confirms preliminary findings, the demand for GLP-1 drugs is likely to increase.

People who are sedentary more than 10 hours per day may have a higher risk of later developing dementia than those who spend less time being inactive, according to a 2023 study.

Both loneliness and isolation were associated with poor health outcomes in a 2023 study. However, social isolation was a stronger predictor of physical decline and early death, while loneliness was more predictive of mental health issues such as depression.