Alzheimer's Archive

Exercising, maintaining good health, socializing, and learning new information may help keep you sharper, longer.

Everyone wants to live an active, vibrant life for as long as possible. And that goal depends on robust brain health. While we don't have a guaranteed way to prevent dementia, we do have increasing evidence that engaging in healthy lifestyle habits may help.

For example, a 2015 randomized controlled trial from Finland suggested that older adults with a number of healthy habits — such as eating a healthy diet, exercising regularly, and socializing — improved or maintained thinking skills and reduced the risk of cognitive decline.

News briefs

 Image: © Andy Dean/Thinkstock

Many studies have suggested that drinking alcohol in moderation — one drink per day for women, one or two drinks per day for men — may offer some protection against heart disease. But a study published June 6, 2017, in The BMJ suggests that moderate alcohol drinking may not protect the brain. Researchers studied over 500 men and women, average age 43, who reported the number and size of alcoholic drinks they had each day. Participants underwent tests of their thinking skills periodically and had MRI scans of their brains at the end of the study. A typical drink was considered to be a 12-ounce beer or a 5-ounce glass of wine. The results after 30 years: drinking just over seven typical drinks or less each week did not appear to either hurt or protect brain health. But drinking eight drinks or more per week was associated with shrinkage in the hippocampus (important to memory) and deterioration of white matter (part of the brain's internal wiring), both of which are associated with decline in thinking skills. The study was observational and did not prove that drinking alcohol caused mental decline. The jury is still out, but this study suggests that it would be wise to avoid averaging more than one alcoholic drink per day.

In the journals

A study published online May 17, 2017, by JAMA Psychiatry found that while depression symptoms later in life were associated with dementia, having symptoms in midlife was not. The findings indicate that depression may not be a risk factor for dementia as previously thought, according to the researchers. In the study, about 10,000 people (two-thirds of them men), ages 35 to 55, were recruited and followed for 28 years. Those who reported chronic or recurring depression symptoms at the study's beginning did not show a significant increased risk of developing dementia by the study's end. However, those who reported depression symptoms within the final 11 years of the study were twice as likely to be diagnosed with dementia.

The researchers said that if depression symptoms were a true risk factor for dementia, there would be an association with people who had symptoms earlier in life and not just later. They concluded that depression later in life instead might be an early sign of dementia.

In the journals

 Image: © jimfeng/Thinkstock

A study in the December 2016 Journal of Nutrition, Health & Aging showed that drinking tea frequently is associated with a lower risk of dementia, especially for people who are genetically predisposed to the disease.

Researchers followed 957 older adults, average age 65, who were part of the Singapore Longitudinal Aging Study. Of these, 69% drank tea on a frequent basis. After a five-year period, the researchers found that the tea drinkers had a 50% lower risk of dementia. This is consistent with earlier findings that showed tea consumers scored higher on various cognitive tests.

Creative activities can relieve stress, aid communication, and help arrest cognitive decline.

 Image: © Katherine A. Gallagher Integrative Therapies Art Therapy Program at the Mass. General Cancer Center

The title of a recent documentary film, I Remember Better When I Paint, sums up the findings of a growing body of research into the cognitive effects of making art. The movie demonstrates how drawing and painting stimulated memories in people with dementia and enabled them to reconnect with the world. People with dementia aren't the only beneficiaries. Studies have shown that expressing themselves through art can help people with depression, anxiety, or cancer, too. And doing so has been linked to improved memory, reasoning, and resilience in healthy older people.

By the time memory loss shows up, the disease is well under way. Researchers are finding ways that may reveal brain changes sooner.

For a long time, memory loss was seen as the telltale sign of Alzheimer's disease. While this is certainly the most common symptom, it may not be the best way to identify the disease in its early stages.

"A major problem of Alzheimer's diagnosis, and ultimately effective treatment, is that by the time the first clinical symptoms appear, irreversible damage to the brain has already occurred," says Dr. Seth Gale, a neurologist with Harvard-affiliated Brigham and Women's Hospital. "It is now believed that Alzheimer's-related changes begin in the brain at least a decade before any symptoms emerge."

In the journals

Much research has shown that oxidative stress plays a key role in the development of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. As a result, antioxidant supplements like vitamin E and selenium have been proposed to prevent dementia. Yet a new study on older men published online March 20, 2017, by JAMA Neurology found no evidence they can help.

The Prevention of Alzheimer's Disease by Vitamin E and Selenium clinical trial included 7,540 men, average age of 67. Over a five-year period, the men were randomly assigned to receive 400 international units of vitamin E each day, 200 micrograms of selenium, both supplements, or a placebo. The supplements were stopped and 3,786 of these men agreed to be followed for an additional six years. They were routinely screened for cognitive problems and encouraged to see their doctor if the results suggested any kind of cognitive impairment.

Research we're watching

Although hormone therapy was once thought to help preserve cognitive function after menopause, there is mounting evidence to the contrary, including a recent report from the Kuopio Osteoporosis Risk Factor and Prevention Study.

Researchers in that project sent questionnaires to all women ages 47 to 56 who lived in the Finnish province of Kuopio in 1987. The women completed questionnaires every five years, providing information about their lifestyles, medication use, and illnesses. The researchers checked the information in the questionnaires against prescription registries and medical records up to 2009.

Research we're watching

Aging brains often show signs of microscopic strokes, which result from damage to tiny blood vessels within the brain. Those that occur in the brain's outermost layer — called cortical cerebral microinfarcts (CMIs) — usually don't cause any symptoms. But they are more common in autopsies of people diagnosed with dementia. Now, new research suggests a link between blood markers for early heart disease and CMIs.

The study, published online Feb. 6, 2017, by JAMA Neurology, included 243 people who attended a memory clinic. All had brain scans to check for CMIs and blood tests that measured two substances associated with early signs of heart damage. People who had CMIs (nearly 29% of the participants) were much more likely to have heart disease than those who didn't have CMIs. Higher levels of both substances associated with heart damage were also linked to CMIs — even when the researchers left out people who already had obvious symptoms of heart disease.

In the journals

A study of almost 31,000 men whose prostate cancer had not spread found that the use of androgen deprivation therapy (ADT) was not associated with a higher risk of Alzheimer's disease. This counters previous studies that suggested a possible link. The results were published in the January 2017 Journal of Clinical Oncology.

ADT is used in prostate cancer treatment to eliminate testosterone, since the hormone can fuel the disease. Testosterone levels also are traditionally lower in men with Alzheimer's compared with control groups, which suggests there may be a connection between lowering testosterone and an increased risk of Alzheimer's. Previous studies that have explored this connection found that a low testosterone level caused by ADT was associated with a higher probability of developing Alzheimer's. But these studies often covered a shorter time period — for instance, one year or less — and it is doubtful that men were on ADT long enough to cause Alzheimer's.