Heart Attack Archive

A polygenic risk score for heart disease is based on an analysis of more than three million common DNA variants and is expressed as a percentile. People can have zero, one, or two copies of any variant, each of which may either raise or lower the risk of coronary artery disease. Many of these variants occur in genes known to affect heart disease, such as those related to cholesterol, blood pressure, and blood clotting. Others aren't well understood and may provide targets for future research, potentially fueling new drug discovery efforts. For now, the potential benefits of this test are greatest for people under 50.

A 2023 Harvard study found that regularly squeezing a week's worth of exercise (150 minutes) into just one or two days—a "weekend warrior" approach—is linked to the same heart-healthy benefits as daily exercise.

There are two different mechanisms by which most heart attacks happen. Both are related to insufficient blood flow to an area of the heart, most often secondary to fatty plaque buildup in coronary arteries. Chest pain remains the most common heart attack symptom, but others are often subtle, and the underlying process causing the heart attack can differ. It's important for people to recognize the different signs of heart attacks, so they know when to seek immediate medical care.

Accelerated cognitive decline may be more common after a heart attack, probably because the same factors that lead to narrowed heart arteries (the root cause of most heart attacks) can also cause tiny, silent strokes. An accumulation of these strokes shows up as bright areas (called white matter lesions) on an MRI scan. These lesions are markers of typical cognitive changes that occur with age. But people who have heart attacks likely have more white matter lesions and experience even greater cognitive decline.

Anxiety disorders promote the stress response, which influences the same brain systems that affect cardiovascular functions.

Research into the health benefits of alcohol has not provided a clear answer. Some findings suggest that alcohol helps protect against heart disease and lowers the risk of heart attacks and strokes, and drinkers tend to live longer than nondrinkers. Other studies say these benefits are less clear. If you don't drink alcohol now, there are no health reasons to start drinking. If you do enjoy it, it's best to have no more than 2 drinks in the same day.

Peripheral artery disease (PAD), which occurs when fatty deposits clog arteries outside the heart, is underrecognized and potentially dangerous. The hallmark symptom is leg pain that occurs with exercise, called intermittent claudication. PAD is more common among people who are older, who smoke, and who have diabetes. The recommended treatment involves short periods of walking interspersed with rest periods when pain occurs. Walking increases blood flow in the leg's smaller arteries and helps create new channels to move blood around the blockages; it also helps discourage new blockages.

New imaging techniques that use light or sound waves to create images of the inside of coronary arteries have helped researchers better understand the fat-laden plaque that builds up inside artery walls (atherosclerosis). Most heart attacks happen when small, inflamed areas of fatty plaque rupture suddenly, causing a clot that blocks blood flow. This may explain why treating large, obstructive plaques with stents or bypass surgery does not seem to prevent heart attacks or help people live longer.