Diseases & Conditions Archive

Forgoing drugs that slow bone loss to avoid rare side effects can be the wrong decision for your hips and spine.

 Image: wildpixel/Thinkstock

A front-page article in the June 1, 2016, edition of The New York Times carried this headline: "Fearing drugs' rare side effects, millions take their chances with osteoporosis." The article described a situation all too familiar to doctors. Women are declining prescriptions of bisphosphonates—drugs that slow the rate at which the body breaks down bone—or discontinuing the medications far earlier than recommended. In fact, according to a 2015 report in the Journal of Bone and Mineral Research, the rate of bisphosphonate use fell by half between 2008 and 2012. That article documented a wave of media coverage of scientific studies that reported two rare side effects—osteonecrosis (bone death) of the jaw and atypical fractures near the top of the femur (thigh-bone)—and suggested that the reports had kindled fears that had led women to abandon bisphosphonates.

"The perception of risk is so much greater than the actual risk," says Dr. Meryl LeBoff, director of the skeletal health and osteoporosis center at Harvard-affiliated Brigham and Women's Hospital. Compared with many other common diseases, we are fortunate that we have good therapies to reduce the risk of osteoporotic fractures by 70% at the spine and 40 to 50% at the hip. She points to statistics referenced in the New York Times article: for every 100,000 women taking a bisphosphonate, fewer than three will have osteonecrosis of the jaw and one will have an atypical femur fracture, but 2,000 will have avoided an osteoporotic fracture.

People who are more physically fit in their mid-to-late 40s may be less likely to have a stroke after age 65 than those who are less fit.

Often referred to as a ministroke , a transient ischemic attack, or TIA, often lasts only minutes, but acts as a warning for a potential full stroke.

Stumble walking across the room? You simply aren't watching your step. Forget a name or can't get out the right words? It's just a fuzzy senior moment. Feeling a little dizzy? You only need to sit down for a second.

The FDA is warning that over-the-counter antacids with aspirin in them can cause stomach bleeding in rare cases. 

Research has found that people with high levels of the oral bacteria Porphyromonas gingivalis had a 59% greater risk of developing pancreatic cancer. It is too early to say whether this specific bacterium directly contributes to the disease. However, one theory is that since inflammation is related to cancer, the bacteria could cause inflammation in the pancreas. Another possibility is the bacteria are simply a marker for cancer-causing inflammation. 

They affect more women, but men still are at risk.

Image: iStock

Most people never think about gallstones—that is until they experience the severe, gut-piercing pain of a gallstone attack. "These often strike after eating, especially a high-fat or high-cholesterol meal, and can last about 30 minutes to two or more hours," says Dr. William Brugge, past director of gastrointestinal endoscopy at Harvard-affiliated Massachusetts General Hospital.

The attacks often begin in the upper-right side of the abdomen and may spread to the back, between the shoulder blades, and under the right shoulder. Nausea or vomiting may also occur.

A study found that the drug ticagrelor (Brilinta) was no better than aspirin at preventing stroke among people who had a mild stroke or a transient ischemic attack (TIA), which mimics stroke-like symptoms. However, ongoing research may show benefits in using the drug in combination with aspirin.

This old standby may not be your first choice for pain relief, but it still has an important role in disease prevention and first aid.

Image: Thinkstock

We have a lot to thank aspirin for. It's cheap and plentiful. It does a good job of relieving pain and bringing down fevers. It has also been shown to reduce the risk of heart attack, stroke, and colon cancer. It can even stop heart attacks and strokes in their tracks. In fact, if you're in your 50s or 60s, you may want to think about taking a low-dose aspirin every day.

After evaluating the results of scores of studies, in April 2016 the U.S. Preventive Services Task Force (USPSTF) recommended that women and men ages 50 through 69 who have a 10% risk of a heart attack or stroke in the next 10 years take 81 milligrams (mg) of aspirin daily. Under the previous recommendations—which, were different for men and women—daily low-dose aspirin was advised for women ages 60 through 79 who were at increased risk for cardiovascular events. The recommendation was revised to reflect a new method of calculating the risk of heart attack and stroke and of increased risk of bleeding in older people.

Often considered an ailment of only military veterans, this condition also can affect many older men.

 Image: Devoryou/Thinkstock

Mention post-traumatic stress disorder (PTSD), and most people immediately think of military veterans. While this group is highly susceptible to PTSD, research has shown that older adults, specifically men, are also vulnerable.

PTSD is a potentially debilitating condition that can occur in people who have experienced a natural disaster, war, terrorism, serious accident, violent personal assault, or similar traumatic event.