Breast Cancer Archive

Can a healthy diet help men with low-risk prostate cancer live longer? The authors of a new study say “yes.” A long-running Physicians’ Health Study, suggests that a diet that is good for the heart, brain, and other parts of the body may also help keep low-risk prostate cancer at bay. On the flip side, a diet rich in red meat and high-fat dairy foods appears to be hazardous for men with this kind of cancer. It isn’t clear why a diet that protects against heart disease would also protect against death from prostate cancer. Dr. Chavarro speculates that it’s because high-fat foods are easily broken down and absorbed by the digestive system, and so they might provide quick energy sources for growing tumors. Nevertheless, the results suggest that by eating healthily, men with prostate cancer can take a proactive step towards living a long life.

An analysis from the Women's Health Initiative (WHI) suggests not only that postmenopausal women who are overweight or obese have a higher risk of invasive breast cancer than women of normal weight but also that the excess risk increases as a woman's weight rises beyond obesity. The results were published online June 11, 2015, by JAMA Oncology.

A team of investigators from several medical centers studied data on 67,000 postmenopausal women who enrolled in the WHI between 1993 and 1998. They were followed for a median of 13 years. During that time, 3,388 invasive breast cancers were detected. The researchers analyzed the distribution of breast cancer among weight classes and calculated the risks for women who were overweight (body mass index, or BMI, of 25 to 30), obese (BMI 30 to 35), or very obese (BMI over 35) compared with women of normal weight (BMI 25 or less). They found that the increased risk of developing breast cancer ranged from 17% in women who were overweight to 59% in those with a BMI over 35. Among women who began the study at a normal weight, those who gained at least 5% of their original weight had a 12% higher risk of developing breast cancer than those who maintained their original weight. Neither losing weight nor using hormone therapy had a significant effect on risk for women of any weight.

A randomized controlled trial of Finnish women over 70 has demonstrated that regular exercise can significantly reduce the risk of serious injury from a fall. Researchers from Tampere University studied 370 women who had fallen during the previous year. They were randomly divided into two groups. One group of 187 participated in classes in which they learned exercises to increase strength, balance, and agility. They attended exercise class twice a week for a year and once a week the next year. They exercised at home on the days they weren't in class. The women in the control group continued their normal routines. All the women kept daily diaries in which they noted whether they had fallen, and if so, the type of injury they sustained and whether they required medical attention. They mailed their diaries to the researchers every month.

At the end of the period, the number of falls was about the same in both groups: 140 in the exercise group and 141 in the control group. The consequences of those falls, though, differed noticeably between the groups: women in the exercise group had 20 falls requiring medical attention, including eight fractures and six head injuries. That compared with 39 such falls in the control group, involving 14 fractures and 12 head injuries.

Participants in the Women's Health Initiative Memory Study (WHIMS) have provided a trove of information. They completed monthly questionnaires and underwent cognitive tests. Those who showed significant decline were also tested for dementia.

Recently, researchers analyzed data from 7,444 participants over 65. They had followed the women an average of seven years. Their report was published online June 15, 2015, by Alzheimer's & Dementia.

There's no guarantee you can prevent cancer, but you can reduce the risk of developing it by making lifestyle changes.

If a growth or mole looks like a melanoma, the doctor will take a biopsy to confirm the diagnosis. This entails removing either a sample of tissue or else the entire growth and some surrounding skin, and examining the tissue under a microscope to determine whether it's cancer. Depending on how deep a melanoma is, additional tissue may have to be removed. In some cases, lymph nodes may be removed, too. A procedure called sentinel node biopsy can show whether the lymph node nearest the tumor contains any cancer cells. If it does, surgery to remove additional nodes right away can improve survival.

In addition to surgery, treatments for melanoma include immunotherapy (which strengthens the immune system against the cancer), chemotherapy, and radiation therapy. Newer, so-called targeted treatments include drugs that target specific genetic changes seem in people with certain forms of melanoma. For example, about half of melanomas have genetic changes (mutations) in a gene called BRAF, which signals melanoma cells to grow and divide quickly. Drugs that inhibit BRAF, such as vemurafenib (Zelboraf ) and dabrafenib (Tafinlar), and related proteins are now available.

As estrogen levels fall during menopause, a woman's risk of depression triples. Estrogen therapy helps elevate mood for some women, but a study published in the May 27, 2015, issue of JAMA Psychiatry has indicated that depression may recur once women stop using estrogen.

A team of researchers at the National Institute of Mental Health studied 56 postmenopausal women, 26 of whom had a history of depression and 30 who had never been depressed. The women were each given an estrogen patch to wear for three weeks and tested for depression. None were depressed.

Active and retired servicemen with prostate cancer can get access to clinical trials, experimental therapies, and state-of-the-art care through the Department of Defense’s Center for Prostate Disease Research (CPDR).

Q. I heard that there is a new stool test for colon cancer screening. Can this test replace colonoscopy for me? I am 68 years old with no history of colon problems, and my last colonoscopy was normal.

A. Among screening tests for hidden colorectal cancer, colonoscopy remains the "gold standard" because it's the most effective technique for detecting colon cancers and simultaneously provides an opportunity to remove any precancerous growths (polyps). The new DNA-based stool test (Cologuard) is less invasive and inconvenient than colonoscopy and finds more cancers and polyps than older stool tests, but it does not entirely eliminate the need for colonoscopies.