Sleep Archive

People who regularly worried about the future and dwelled on the past saw larger drops in cognition and had more harmful brain proteins than those who didn't.

Chronic worrying or ruminating could be bad for your brain. A study published online June 7, 2020, by Alzheimer's & Dementia linked these negative thinking patterns to brain changes that could be associated with Alzheimer's disease.

Study authors found that older adults who regularly engaged in what the authors called repetitive negative thinking were more likely to experience cognitive decline, including memory problems, than those who didn't. They also had higher levels of the proteins beta-amyloid and tau in their brains. The accumulation of these proteins, which create damaging clumps known as plaques and tangles in the brain, is a hallmark of Alzheimer's that begins in the earliest stages of the disease — even before an individual experiences visible symptoms of dementia.

With the introduction of benzodiazepines such as chlordiazepoxide (Librium) and diazepam (Valium) in the early 1960s, a new era in the treatment of insomnia and anxiety began. The benzodiazepines were more effective and far safer than the older drugs — barbiturates, meprobamate, and glutethimide — that had been prescribed for these purposes. For many years, benzodiazepines continued to be the most popular prescription tranquilizers and sedatives. Since the mid-1980s, new alternatives have been assuming some of these roles, but benzodiazepines are not about to leave the stage.

More than a dozen benzodiazepines are available by prescription. Benzodiazepines have a common basic chemical structure, and they all increase activity at receptors for the neurotransmitter gamma-aminobutyric acid (GABA). This transmitter inhibits the activity of neurons, slowing down the brain and nervous system. Benzodiazepines differ mainly in how quickly they are absorbed, how long their effects last, and how long they take to leave the body.

It’s well known that getting enough sleep is critical to daily functioning and long-term health. Now, new research suggests that a lack of enough REM sleep may be related to earlier death in people at middle age or older.

Research we're watching

People with chronic pain may be more likely to have a heart attack or stroke than those without chronic pain, according to a study published online May 7, 2020, by the journal Pain Medicine.

From 2001 to 2005, researchers identified 17,614 Taiwanese people who had used pain relievers for at least three months. The most common causes of pain were spinal disorders, arthritis, and headaches; the pain relievers included both over-the-counter drugs and prescription opioids. For the comparison group, researchers used 35,228 people without chronic pain who were matched by age and sex to those in the first group.

Ask the doctor

Q. My husband is reluctant to get tested for sleep apnea. But I'm pretty sure that he has it, and I'm concerned because I've heard that it can contribute to heart disease. How are these two conditions connected?

A. As you likely know already, people with sleep apnea may snore loudly and may also periodically gasp for breath throughout the night. These explosive snorts often wake up bed partners or roommates — although not necessarily the person with apnea.

Having your sleep interrupted by the need to urinate (the medical term is nocturia) is a common cause of sleep loss, especially among older adults. Nearly two-thirds of adults ages 55 to 84 deal with this problem at least a few nights per week.

People with mild cases may wake two times a night; in severe cases, it may be as many as five or six times. The result can be significant sleep loss and daytime fatigue.

Some ideas seem reasonable, but that doesn't mean they'll help.

People increasingly consult the Internet about medical problems. If you're looking for approaches to relieve joint pain and inflammation caused by wear and tear (osteoarthritis) or an immune system attack (such as occurs in rheumatoid arthritis), you may find methods that sound promising and even sensible. But will they work? Here's advice on five pain relief methods commonly touted on the Internet.

1. Music therapy

Listening to music can evoke powerful emotions that help people relax or heal, which is the basis of music therapy. Research has found that music therapy is associated with less anxiety before surgery or during chemotherapy, and better functioning during physical rehabilitation.