Alzheimer's Disease Archive

Men need to be challenged to be healthy in mind and body.

It might seem like retirement is a time to take it easy and devote yourself to gardening, golfing, and napping. But don't take it too easy, say Harvard experts. An absence of challenges can have the same effect as too much stress, compromising your physical and mental health. For optimal well-being, you need to stay engaged—with your own interests as well as with other people.

The best-quality evidence available does not prove that taking a statin can cause memory loss or other changes in mental functioning, according to a review in the Journal of General Internal Medicine. Since 2012, the FDA has required that statin manufacturers include a warning on drug packaging that statins could impair mental functioning, but this has been controversial. Researchers took a look at the published evidence for possible mental side effects of statins.

The new review covered randomized clinical trials involving nearly 47,000 people. Such trials are the gold standard in medical research. These included 23 trials in which researchers explicitly measured mental functioning, as well as trials that kept track of mental changes reported by participants.

High blood sugar may add to mental decline in people with cardiovascular disease.

A portable ultrasound device that detects plaque buildup in arteries may offer a simple, cost-effective way to detect heart disease before it causes any symptoms. A report in the December 2014 Global Heart journal describes findings from a large-scale test of the technology in India, the United States, and Canada.

The innermost layer of an artery's wall (the intima) provides a smooth surface for blood to flow through. The middle layer (the media) contains muscle and elastic fibers that let the vessel expand and contract with each heartbeat. The thicker the intima and the media, the more likely the artery is choked with cholesterol-filled plaque. Using ultrasound, a doctor can easily measure the intima-media thickness in the arteries of the neck and upper leg.

The telltale sign is leg pain and fatigue that comes on with activity and goes away with rest.

Anticholinergics, a group of medications that includes many over-the-counter and prescription drugs, are well known for causing confusion in older adults. Common medications with anticholinergic properties include medications to treat overactive bladder, such as oxybutynin (Ditropan); medications to treat allergies and sleeping problems, such as diphenhydramine (Benadryl, Sominex, Unisom); and medications used to treat depression, such as amitriptyline (Elavil). It's generally believed that confusion that may develop from anticholinergics clears up when someone stops taking the drugs. But now it appears that the medications are associated with a more permanent effect. A study published online Jan. 26, 2015, in JAMA Internal Medicine linked daily anticholinergic use among older adults for three or more years to an increased risk for developing dementia and Alzheimer's disease.

The study didn't prove that anticholinergics cause dementia; it only found an association between people who take the medications and people who develop dementia. Nevertheless, the researchers suggest that doctors avoid prescribing anticholinergics when possible, or at least limiting the medications to the lowest doses possible. If you're taking an anticholinergic, talk to your doctor about the risks the medication poses, including the risk of falls as a result of confusion.

Although these powerful pain relievers can be addictive, opioids are safe for most people when used properly.

Q. My doctor has recommended a bone density screening, but the medical center with the full-body scanner is a 45-minute drive from my house. A health fair at a neighborhood church offers a bone density test using a foot scanner. Would that be as accurate?

A. The foot scan is called a quantitative ultrasound, and it usually measures the bone density of the heel bone.
It appears to be at least as good as clinical risk factors—such as older age, family history of bone fractures, low body mass index, smoking, corticosteroid use, and excessive alcohol consumption—for identifying people at high risk for osteoporosis.

For most people, there is no advantage to tests that measure cholesterol and triglyceride particle size.

At middle age, the brain begins to draw on more of its capacity for improved judgment and decision making.

If you forget a name or two, take longer to finish the crossword, or find it hard to manage two tasks at once, you're not on the road to dementia. What you're experiencing is your brain changing the way it works as you get older. And in many ways it's actually working better. Studies have shown that older people have better judgment, are better at making rational decisions, and are better able to screen out negativity than their juniors are.