Mind & Mood Archive

There are currently nine trials of vaccines for Alzheimer's disease under way. All of them are in people with mild Alzheimer's or with the pre-Alzheimer's condition called mild cognitive impairment. All of the vaccines are designed to encourage the immune system to remove protein deposits from the brain. Most experimental vaccines are given by injection; one being tested at Harvard Medical School uses a nasal spray. It will be several years before we know if any of them will work.

A 2025 study finds that a first-time transient ischemic attack (TIA) can lead to the same long-term decline in thinking and memory problems as a full-blown stroke. Experts suggest cognitive testing after a TIA. People who have TIAs should take extra care to address risk factors for heart attack and stroke, such as high blood pressure and high cholesterol. Exercising regularly and staying socially active may help ward off cognitive decline.

In a 2025 study, people with the healthiest diets and trimmest bellies at midlife had better brain connections and skills decades later, compared with people who ate the worst diets and had the most belly fat.

A 2025 study suggested that getting the shingles vaccine can significantly reduce the likelihood of developing dementia, especially among women.

Mindfulness might help improve attention and memory. Mindfulness is the practice of focusing on the present moment, including thoughts, feelings, and all information coming in from the senses, such as sights, sounds, and smells. Many studies have shown that mindfulness helps people improve well-being, concentrate, engage more effectively in daily activities, and pay more attention. Attention is the most crucial factor when it comes to memory; whatever someone pays attention to is what he or she remembers.

Doctors are optimistic that artificial intelligence (A.I.) will one day play a role in curing and preventing Alzheimer's disease. One example of A.I.'s application is its use in helping scientists learn how certain molecules might cause Alzheimer's.

A 2025 study found that the shingles vaccine reduced the risk of developing dementia by 20%. The study supports (but doesn't absolutely prove) the theory that infections may be one cause of Alzheimer's disease and possibly other forms of dementia.

A 2025 study found that chronic stress is associated with higher stroke risks among women under 50, but not in men.

Approximately 50 million adults experience some daily pain. These people usually encounter fluctuations in pain during the day, but in many cases, the pain worsens at night, disrupting sleep. Many strategies can be adopted to prevent and manage nighttime pain, such as doing a pre-bedroom relaxation routine, creating a healthy sleep environment, reframing negative thinking, changing sleeping positions, and using supportive pillows.