Digestive Health Archive

News briefs

First it was certain blood pressure and heartburn drugs; now some medications used to treat type 2 diabetes are being recalled because of cancer concerns. The FDA warned in late May and early June 2020 that some lots of extended-release metformin may contain unacceptable levels of N-nitrosodimethylamine (NDMA), a possible cancer-causing chemical. At least five manufacturers are now issuing voluntary recalls of the medications. But if you take extended-release metformin, don't just stop on your own. Not all extended-release metformin products are affected by the voluntary recalls, and stopping any medication that controls blood sugar can be very dangerous. The FDA advises that you check in with your doctor or pharmacist. Ask if your medication is affected by the recall; if so, ask if you should switch to another version of the drug.

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Research we're watching

A new tool to identify people who might be at higher risk for pancreatic cancer could help doctors find cases earlier, when they are most treatable. Researchers from the Harvard T.H. Chan School of Public Health created a risk model that did a better job than current models of finding people at high risk for the disease. It takes into account clinical and genetic factors as well as blood levels of biomarkers (substances that could potentially indicate disease). To test the model researchers used data from four large clinical studies. They applied the tool to 500 known pancreatic cancer patients and more than 1,000 people without cancer. The researchers then assessed how well the tool would have predicted the risk of pancreatic cancer. Pancreatic cancer, which is the third leading cause of cancer death in the United States, is challenging to treat because most people already have advanced disease when they are diagnosed. It's hoped that identifying people who are at high risk will eventually allow doctors to screen these individuals to find cancers when they are smaller and more curable.

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In the journals

Scientists continue to explore the health benefits versus risks of aspirin therapy. One new analysis suggests that taking aspirin may protect against several types of digestive tract cancers. The results were published online April 1, 2020, by Annals of Oncology.

Researchers examined 113 observational studies of cancer in the general population. They found that individuals who took aspirin regularly — at least one or two tablets a week — had significantly lower rates of cancers of the bowel, stomach, gallbladder, esophagus, pancreas, and liver, compared with people who did not take aspirin.

Most people understand the risks of sun exposure, even if they do not regularly wear sunscreen, but getting younger people to pay attention to this concern can be difficult. A study chose a novel approach to this problem by appealing to teenagers’ vanity and focus on their appearance.

Tinted sunscreens offer all the benefits of traditional sun protection products, plus they have added pigments that give them the ability to block visible light, which can also be harmful to the skin.

People with irritable bowel syndrome (IBS) may take probiotics to try to restore the balance of bacteria in their gastrointestinal tract. A recent study found that an inactive form of a probiotic (which has some advantages over active versions) helped improve symptoms and quality of life in test subjects.

Research we're watching

According to a report published March 12 in the journal Cancer, the rate of death from cancer has continued to decline in the United States, dropping on average 1.5% a year from 2001 to 2017. The decline showed up for all ethnic and age groups between 2013 and 2017. The findings were based on cancer incidence data collected by the CDC and the National Cancer Institute.

But not all news was good: the number of new cancer diagnoses in women rose slightly during 2012 to 2016. A more detailed look at cancer deaths among women found a drop in cancer deaths for a majority of the most common cancers, including breast cancer, melanoma, lung cancer, and colorectal cancer. But deaths in women increased when it came to uterine, brain, liver, heart, and pancreatic cancer.