Alzheimer's Disease Archive

The jury is still out, but magnetic fields or mild electric currents may aid learning and help several conditions that affect women in particular.

Stimulating your brain doesn't just mean spending an evening at the theater or reading a good book. These days it can involve sitting with your head against a magnet or wearing electrodes that transmit a low-voltage current through your scalp to activate—or suppress—certain neurons in your brain. The prospect of regulating brain signals responsible for mood, pain, and learning is so compelling that scores of studies are under way to see if, and how, the approach can be used to sharpen mental skills and treat symptoms of several mind-body disorders. "Brain stimulation, if used carefully and safely, looks promising, especially if combined with other therapies," says Dr. Daniel Press, a neurologist with the Berenson-Allen Center for Noninvasive Brain Stimulation at Harvard-affiliated Beth Israel Deaconess Medical Center. Dr. Press has used noninvasive brain stimulation for almost a decade.

Ask the doctor

Q. Recently, I felt very agitated and out of control, crying and angry about things I could ordinarily handle with ease. I was starting fights with my husband and others over relatively insignificant issues. I had been taking synthetic thyroid hormone for several decades and had very low levels of thyroid-stimulating hormone in my blood. I've stopped taking the hormone and feel better, but I feel bad about the way I snapped at my friends and family. Could thyroid hormone have been to blame for my behavior?

A. It could very well have been responsible. Low thyroid-stimulating hormone (TSH) levels mean that thyroid hormone levels are increasing. Anxiety, agitation, and restlessness are all signs of hyperthyroidism—an overactive thyroid gland or, in your case, too much thyroid hormone medication. You can let your husband and friends know that your irritability was probably caused by too high a dose of your prescription and not a permanent change in your disposition.

Participants in the Women's Health Initiative Memory Study (WHIMS) have provided a trove of information. They completed monthly questionnaires and underwent cognitive tests. Those who showed significant decline were also tested for dementia.

Recently, researchers analyzed data from 7,444 participants over 65. They had followed the women an average of seven years. Their report was published online June 15, 2015, by Alzheimer's & Dementia.

The world moves at a hectic pace these days. If you feel like you're constantly running on empty, you're not alone. Many people say that they just don't have the energy they need to accomplish all they need to. Sometimes the cause of fatigue is obvious — for example, getting over the flu or falling short on sleep. Sometimes a vitamin deficiency is part of the problem. It might be worth asking your doctor to check a few vitamin levels, such as the three we've listed below.

• Iron. Anemia occurs when there aren't enough red blood cells to meet the body's need for oxygen, or when these cells don't carry enough of an important protein called hemoglobin. Fatigue is usually the first sign of anemia. A blood test to measure the number of red blood cells and amount of hemoglobin can tell if you have anemia. The first step in shoring up your body's iron supply is with iron-rich foods (such as red meat, eggs, rice, and beans) or, with your doctor's okay, over-the-counter supplements.
   
• Vitamin B₁₂. Your body needs sufficient vitamin B₁₂ in order to produce healthy red blood cells.  So a deficiency in this vitamin can also cause anemia. The main sources of B₁₂ are meat and dairy products, so many people get enough through diet alone. However, it becomes harder for the body to absorb B₁₂ as you get older, and some illnesses (for example, inflammatory bowel disease) can also impair absorption. Many vegetarians and vegans become deficient in B₁₂ because they don't eat meat or dairy. When B₁₂ deficiency is diet-related, oral supplements and dietary changes to increase B₁₂ intake usually do the trick. Other causes of B₁₂ deficiency are usually treated with regular injections of vitamin B₁₂.
   
• Vitamin D. A deficit of this vitamin can sap bone and muscle strength. This vitamin is unique in that your body can produce it when your skin is exposed to sunlight, but there also aren't many natural food sources of it. You can find it in some types of fish (such as tuna and salmon) and in fortified products such as milk, orange juice, and breakfast cereals. Supplements are another way to ensure you're getting enough vitamin D (note that the D₃ form is easier to absorb than other forms of vitamin D).

For more ways to combat fatigue, buy Boosting Your Energy, a Special Health Report from Harvard Medical School.

Get to know your triggers and ways to prevent flare-ups.

If a growth or mole looks like a melanoma, the doctor will take a biopsy to confirm the diagnosis. This entails removing either a sample of tissue or else the entire growth and some surrounding skin, and examining the tissue under a microscope to determine whether it's cancer. Depending on how deep a melanoma is, additional tissue may have to be removed. In some cases, lymph nodes may be removed, too. A procedure called sentinel node biopsy can show whether the lymph node nearest the tumor contains any cancer cells. If it does, surgery to remove additional nodes right away can improve survival.

In addition to surgery, treatments for melanoma include immunotherapy (which strengthens the immune system against the cancer), chemotherapy, and radiation therapy. Newer, so-called targeted treatments include drugs that target specific genetic changes seem in people with certain forms of melanoma. For example, about half of melanomas have genetic changes (mutations) in a gene called BRAF, which signals melanoma cells to grow and divide quickly. Drugs that inhibit BRAF, such as vemurafenib (Zelboraf ) and dabrafenib (Tafinlar), and related proteins are now available.

Extra-virgin olive oil and nuts seem to contribute to the benefits.

A heart-healthy lifestyle is strongly associated with better memory and lower risk of Alzheimer's disease.

The health press is full of claims that "superfoods"—like fresh berries and leafy greens—can keep your memory sharp and hold the threat of Alzheimer's disease at bay. But for now, the evidence is preliminary at best. Your safest bet is to lead an overall heart-healthy lifestyle—including eating a plant-based diet and getting regular exercise—rather than drawing up a shopping list of alleged brain-boosting superfoods.

Physical therapy is helpful for wear-and-tear knee osteoarthritis, especially if you start doing it early. But injecting a painful knee with an anti-inflammatory steroid medication before starting physical therapy offers no additional benefit, according to a clinical trial in JAMA Internal Medicine.

Studies have shown that physical therapy modestly reduces pain and improves daily functioning in people with knee osteoarthritis. That could mean being able to walk farther with less pain or to continue leisure activities such as gardening. Before you start physical therapy, your doctor may offer to inject the knee with a cocktail of anti-inflammatory steroid medication and an anesthetic. Hypothetically, this could make it easier for you to stick with exercise and therefore lead to better results.

A driving assessment program can help identify your strengths and weaknesses and suggest ways to improve your driving skills.

The sense of freedom and independence that comes with driving is as important at 65 as it is at 16. But driving skills may start to falter as we age, an issue many people choose to ignore. "We all seem to be in denial about driving in our older years. No one wants to give it up. The good news is that you may not have to," says Lissa Kapust, a social worker at Harvard-affiliated Beth Israel Deaconess Medical Center.