Alzheimer's Disease Archive

For many women, bunions and rigidity are two of the most common—and painful—problems with the big toe. Both are easily treated.

Reports at the Alzheimer's Association International Conference in July 2015 verified that women are at higher risk than men for developing Alzheimer's, and also progress more rapidly from mild cognitive impairment to out-right dementia than men do. But not all the news was bad. A study reported at the meeting indicates that physical exercise can halt, and even reverse, the decline in people with mild cognitive impairment.

In that study, conducted by researchers at Wake Forest University in North Carolina, 65 previously sedentary women and men with mild cognitive impairment exercised at peak capacity for at least 45 minutes four times a week for six months. At the beginning and end of the study, researchers tested participants' cognitive skills and examined their blood and cerebrospinal fluid for levels of tau protein—a principal component of the amyloid plaques associated with Alzheimer's disease. They found that the participants scored significantly higher on the cognitive tests at the end of the study than they had at the beginning. Their tau protein levels had declined substantially as well.

We know that moderate-intensity exercise, such as brisk walking, can both improve thinking skills and slow their decline in older age. Now a trio of studies presented at the July 2015 Alzheimer's Association International Conference suggest that aerobic exercise may even be able to help protect your brain from Alzheimer's and other dementias, and improve your quality of life if you have the disease. One study of 200 adults with Alzheimer's showed that those who engaged in three hour-long exercise sessions a week for 16 weeks had less anxiety, irritability, and depression and better mental speed and attention compared with those who didn't exercise. A study of 65 sedentary older adults with mild cognitive impairment showed that those who took part in 45 to 60 minutes of aerobic exercise four times a week for six months not only had better attention and planning skills, but also better blood flow to the brain and a reduction in dangerous proteins associated with Alzheimer's disease, compared with those who only did stretching exercises. A study of 71 older adults with cognitive impairment due to vascular disease found that those who did an hour of aerobic exercise three times per week for six months improved their thinking skills, memory, and attention compared with those who did not exercise. Although the studies were presented at a scientific meeting, it's only after publication of the full details that scientists can adequately judge a work. Nevertheless, the studies are in line with past research showing that regular exercise may help protect the brain.

Atrial fibrillation (afib) is affecting far more people than it did 50 years ago, according to a study published July 11, 2015, in The Lancet. Afib is an irregular heartbeat that makes the heart's upper chambers (the atria) quiver, rather than pump steadily. This can lead to the formation of blood clots, which can travel in the blood to the brain and cause a stroke. The Lancet study found that afib cases quadrupled from 1958 to 2007 among 9,500 people. But there is some encouraging news: the study also found that the risk of stroke associated with afib decreased 74% in the last 50 years, and the risk of death decreased 25%.

Why the ups and downs? Researchers point to epidemics of obesity and diabetes as part of the reason, as well as increased awareness of the condition and better detection methods. Meanwhile, improved recognition and treatment of other diseases, such as high blood pressure, may be helping to reduce the cases of stroke and early death linked to afib. So, this study provides further evidence of the importance of maintaining a healthy weight and keeping blood sugar, blood pressure, and cholesterol under control. In addition to reducing the risk of heart disease, stroke, diabetes, and other illnesses, you also reduce the risk of getting afib and developing complications from it.

Repeated nocturnal bathroom calls are bothersome, but self-help steps and targeted treatment offer relief.

With aging, the body and mind change—but it's not all bad.

Aging brings physical changes and a greater risk of health problems—no one needs to tell you that. The mind changes too, and we grumble about things like increased forgetfulness. But the aging mind bestows some gifts, too.

Q. My doctor used to check my liver function once a year after I started taking a statin drug to lower my cholesterol, but he doesn't anymore. Why not?

A. Your doctor appears to be following the latest recommendations from the American Heart Association and the FDA. When statin medications were first approved, doctors did periodic blood tests to check for liver injury. Three decades later, it is clear that serious liver injury from statins is a rare side effect and that routine blood testing does not help identify people at risk for statin-related liver problems. Therefore, routine monitoring is not a good use of money and time.

Boosting your fitness level may help decrease the symptoms of the most common heart rhythm disorder, according to a study published online June 22 by the Journal of the American College of Cardiology. The disorder—atrial fibrillation, or afib—causes an irregular, rapid heartbeat that can lead to shortness of breath, dizziness, and fainting.

The study included 308 people with afib who were also overweight or obese, a condition that raises the risk of afib. The participants answered questions about their afib symptoms and underwent tests to determine their fitness levels, which were described in metabolic equivalents, or METs. (METs measure your level of exertion and are based on how much oxy-gen your body uses during activities; sitting still is 1 MET, and brisk walking is 3.)

There are many different ways to find comfort when grieving. Some people find that spirituality or organized religion is a source of great solace. Specific rituals and rites — whether sitting shiva, setting up an altar inside your home, or gathering at the cemetery once a year — can draw people together and encourage them to share their grief. Attending religious services can link you with a well-defined community primed to offer help of all sorts. And a kind word, a willing listener, a shared meal, and any number of large and small acts of assistance help keep people afloat and ease their distress after a death.

Religious or spiritual beliefs may also help by lending larger meaning to a loved one's life and death. For some, the belief that a loved one is enjoying the spiritual riches of heaven or preparing for the next turn of the wheel through reincarnation can be comforting. Believing your loved one helps guide you in this world or that you will be reunited in another place after your own death can help you continue to feel connected with the person.

Ask the doctor

Q. What's the fastest way to get rid of a cold sore? Is it possible to prevent them?

A. Cold sores, also called fever blisters, are bothersome and painful fluid-filled blisters on or around the lips. They are caused by infection with herpes simplex virus (usually type 1). Cold sores heal on their own in seven to 10 days. However, antiviral medications can modestly shorten the healing period. One-day treatment with the prescription antiviral drugs famciclovir (Famvir) or valacyclovir (Valtrex) shortens cold sore symptoms by one to two days. These oral medications are most effective when taken at the first sign of a cold sore, such as a burning or tingling sensation. Antiviral creams are less effective and need to be applied several times daily for five days.