Medications Archive

Topical painkillers might be safer than pills to relieve discomfort from muscle strains (like a pulled hamstring) or ligament sprains (like a sprained ankle). This is because topicals target the area of pain. As a result, other parts of the body are exposed to lower levels of medicine. That’s important, since some painkillers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can pose severe risks—such as heart attack and stroke.

A 2025 study found that a pill version of the drug semaglutide, marketed as Rybelsus, can lower the risk for serious heart problems in people who have diabetes as well as cardiovascular disease, kidney disease, or both.

In a 2025 study, researchers estimated that fewer than four emergency department visits attributed to semaglutide (Ozempic, Wegovy) occurred for every 1,000 patients taking the drug in 2022 and 2023. Most of the visits were related to gastrointestinal problems.

In the last few years, the prescribing rate for zolpidem, a popular sleeping pill, has been declining in favor of the "off-label" use of an antidepressant called trazodone, which is known for its ability to make people drowsy. But doctors are concerned that trazodone hasn't been well studied for insomnia, it is not FDA-approved to treat the condition, and there are sparse data showing that it is safe or that it works for patients with insomnia. Experts advise choosing medications based on a patient's specific needs, not a trend.

In its 2025 guidelines for treating restless legs syndrome (RLS), the American Academy of Sleep Medicine stopped recommending the long-term use of dopamine agonist drugs, since they can eventually make RLS symptoms worse. Instead, the guidelines strongly recommend another class of medications as the first-line treatment: alpha-2-delta ligands, such as gabapentin (Neurontin), gabapentin enacarbil (Horizant), and pregabalin (Lyrica). Alpha-2-delta ligands do not make RLS symptoms worse.

Certain medications can leave people more vulnerable to heat-related effects or the sun's rays. The medications can raise the risk of dehydration, make people sweat too much or too little, impair the body's ability to regulate temperature, or raise the risk of getting a bad sunburn. In addition, higher temperatures may damage some medicines, including diuretics, blood pressure drugs, some antidepressants, thyroid replacement hormones, and some over-the-counter antihistamines.

A 2025 analysis suggested that GLP-1 medications used for diabetes and weight loss are associated with lower risks for an array of conditions, but that they increase risks for several others.

Direct-to-consumer (DTC) drug ads promoting treatments for arthritis, cancer, heartburn, psoriasis, flagging memory, and more are all everywhere you look. All too often, the information shared is incomplete, biased, or confusing––here's what to watch out for and how to get the whole story when considering treatment options.