Heart Health Archive

Clinical trials are under way using gene therapy to treat inherited cardiovascular conditions, including familial hypercholesterolemia (one form of abnormally high cholesterol), hypertrophic cardiomyopathy (a type of heart muscle disease), and transthyretin amyloid cardiomyopathy (a form of heart failure resulting from amyloid deposits). But challenges remain in developing and delivering these therapies.

About a third of healthy people—and about 60% of people with high blood pressure—are salt sensitive, meaning they have an exaggerated response to dietary sodium. But an estimated one in 10 people may have inverse salt sensitivity: their blood pressure goes up when they eat less salt. Understanding the genetic basis of these differences may one day improve the treatment of blood pressure.

The PREVENT equation is a new online calculator to predict a person's odds of developing heart disease. Compared to previous calculators, the updated tool considers broader measures of health (including biomarkers for kidney and metabolic health) and a longer age span (starting at 30 instead of 40 years of age). The goal is to encourage earlier, more targeted strategies to help people avoid cardiovascular problems.

Tiny mesh tubes called stents, used to prop open heart arteries, can relieve stable angina (chest pain with exertion or emotional stress) in many people with coronary artery disease. But this treatment—which carries a risk of complications and a high cost—should be reserved only for people who don't get relief from drug therapy. Stents do not prevent future heart attacks or improve survival compared with drug therapy. Angina usually results from arteries that are more than 70% blocked, but most heart attacks occur in arteries that are narrowed by only about 40% or less but harbor plaque that ruptures without warning. The resulting blood clot blocks blood flow, triggering a heart attack.

A 2023 study suggests that moving, standing, or even sleeping are all better than sitting for people's weight, waistlines, and heart health.

A 2023 study suggests replacing a daily serving of processed meats with whole grains, nuts, or beans is associated with lower odds of cardiovascular conditions such as heart attack or stroke.

Many studies suggest that fiber-rich diets may help prevent heart disease. But most Americans eat only about 16 grams of fiber a day-far less than the recommended amounts.

Metabolic syndrome is a constellation of interrelated health conditions that significantly increases the risk for heart attacks, strokes, diabetes, and more. A diagnosis requires at least three of the following risk factors: obesity, high blood sugar, high triglycerides, low HDL (good) cholesterol, or high blood pressure. Metabolic syndrome can be reversed if it's recognized. Losing weight is central to reducing many of its features. Lowering elevated blood pressure, blood sugar, and cholesterol levels also plays a major role in reducing the risk for heart disease and stroke.

When participants in a 2023 study ate a low-sodium diet for one week, the vast majority experienced an average 8-point drop in their systolic blood pressure compared to when they ate a high-salt diet for one week.

A 2023 study found that a mindfulness training program that improves self-awareness may help people with high blood pressure follow a heart-healthy diet.