Colorectal Cancer Archive

Research we're watching

A new tool to identify people who might be at higher risk for pancreatic cancer could help doctors find cases earlier, when they are most treatable. Researchers from the Harvard T.H. Chan School of Public Health created a risk model that did a better job than current models of finding people at high risk for the disease. It takes into account clinical and genetic factors as well as blood levels of biomarkers (substances that could potentially indicate disease). To test the model researchers used data from four large clinical studies. They applied the tool to 500 known pancreatic cancer patients and more than 1,000 people without cancer. The researchers then assessed how well the tool would have predicted the risk of pancreatic cancer. Pancreatic cancer, which is the third leading cause of cancer death in the United States, is challenging to treat because most people already have advanced disease when they are diagnosed. It's hoped that identifying people who are at high risk will eventually allow doctors to screen these individuals to find cancers when they are smaller and more curable.

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In the journals

Scientists continue to explore the health benefits versus risks of aspirin therapy. One new analysis suggests that taking aspirin may protect against several types of digestive tract cancers. The results were published online April 1, 2020, by Annals of Oncology.

Researchers examined 113 observational studies of cancer in the general population. They found that individuals who took aspirin regularly — at least one or two tablets a week — had significantly lower rates of cancers of the bowel, stomach, gallbladder, esophagus, pancreas, and liver, compared with people who did not take aspirin.

Most people understand the risks of sun exposure, even if they do not regularly wear sunscreen, but getting younger people to pay attention to this concern can be difficult. A study chose a novel approach to this problem by appealing to teenagers’ vanity and focus on their appearance.

Tinted sunscreens offer all the benefits of traditional sun protection products, plus they have added pigments that give them the ability to block visible light, which can also be harmful to the skin.

Research we're watching

According to a report published March 12 in the journal Cancer, the rate of death from cancer has continued to decline in the United States, dropping on average 1.5% a year from 2001 to 2017. The decline showed up for all ethnic and age groups between 2013 and 2017. The findings were based on cancer incidence data collected by the CDC and the National Cancer Institute.

But not all news was good: the number of new cancer diagnoses in women rose slightly during 2012 to 2016. A more detailed look at cancer deaths among women found a drop in cancer deaths for a majority of the most common cancers, including breast cancer, melanoma, lung cancer, and colorectal cancer. But deaths in women increased when it came to uterine, brain, liver, heart, and pancreatic cancer.

In the journals

Bleeding is a common side effect of anticoagulants (blood thinners). However, people with atrial fibrillation (afib) who take the drug for stroke prevention should not ignore any bleeding from their lower gastrointestinal (GI) tract, as it may signal colon cancer. That study finding was published online Feb. 7, 2020, by the European Heart Journal.

Researchers analyzed 125,418 patients who took anticoagulants for afib. Only 2,576 had lower GI bleeding during the first six months of treatment, regardless of age. Yet those who did experience bleeding had 10 times the risk of being diagnosed with colon cancer during the subsequent year compared with those who hadn't had any bleeding.

Good news on health –– which seems hard to come by right now –– includes declines in the rates of six out of 10 major causes of death in the United States.

Approaches to using laxative solutions for colon cleansing have changed since your last colonoscopy.

Preparing for a colonoscopy isn't fun. Indeed, many people dread the colonoscopy prep more than the colonoscopy itself. Traditionally, you have had to change your diet for a few days, drink quarts of laxative solutions — and then spend hours in the bathroom enduring diarrhea and discomfort as your colon empties. In the past few years, though, the approach to taking laxative solutions has evolved to become a little less unpleasant.

Lower-volume preps

Instead of downing 4 liters of medicated liquid, which was once the standard, most people now need to drink about 2 liters (a bit more than 64 ounces). The reduced volume of laxative fluid is often combined with laxative pills, to help you clear your bowels.