Colorectal Cancer Archive

Colorectal cancer is the second leading cause of cancer deaths in the United States, and rates are rising, particularly in younger people. It can be prevented with screening tests; there are several different types of tests that are performed in different ways, and guidelines for when testing should begin and how often people should be tested.

There are several at-home screening tests for colorectal cancer. The most accurate are a fecal immunochemical test (FIT) and a multitarget stool DNA (mt-sDNA) test (Cologuard), also known as a FIT-DNA test. The FIT test uses antibodies to detect blood in stool, and must be done once a year. The FIT-DNA test can identify DNA from cancer cells in the stool and also has a FIT component to look for blood. This test may be repeated once every three years.

Scary or misleading claims about things that may cause cancer are so plentiful that it's hard to know which ones to take seriously. A new website developed by experts aims to provide reliable information about whether a particular cancer claim is true.

Most people don't benefit from colonoscopies after age 75, but before stopping they should have a discussion with their doctor.

News briefs

Regular aspirin use is associated with a reduced risk for developing colorectal cancer in older age — but you won't get the benefit if you start the therapy too late in life, according to a Harvard study published online Jan. 21, 2021, by JAMA Oncology. Researchers combined the results of two large studies involving a total of more than 94,000 people who answered health questionnaires regularly and were followed for three decades. Compared with people who didn't take aspirin, people ages 70 or older who took either 325 milligrams (mg) or 81 mg of aspirin at least twice per week had a 20% lower risk for developing colorectal cancer — but only if they had started the therapy by age 65. Starting aspirin therapy at or after age 70 was not associated with significant protection against colorectal cancer. The study was observational and does not prove whether aspirin can or cannot ward off colorectal cancer. But other observational studies have also shown an association between aspirin use and lower colorectal cancer risk. Like any medicine, aspirin isn't risk-free: regular use increases the risk for gastrointestinal bleeding. If you happen to be taking aspirin regularly for other reasons, this might be an added benefit.

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