Hidden cancer rarely causes out-of-the-blue clots in the bloodstream

Howard LeWine, M.D.

Chief Medical Editor, Harvard Health Publishing

Blood clots can be lifesavers when they form outside the bloodstream to stop bleeding from an injury. But they can wreak havoc when they form inside the bloodstream. A blood clot in a coronary artery can cause a heart attack. One in the brain can cause a stroke.

Blood clots that form in a leg vein cause a problem known as venous thromboembolism, or VTE. If the clot stays in the leg, it can cause swelling or pain. If it breaks away and travels to the lungs, it can cause a potentially deadly pulmonary embolism.

In about half of people who develop a VTE, doctors can identify what caused it. Common causes include an injury; surgery; pregnancy; taking hormones, such as testosterone or estrogen; an increased risk of clotting due to a genetic disorder or other disease; or slowed blood flow caused by prolonged bed rest, wearing a cast, or sitting for a long time. In the other half, VTE is something of a mystery. These are called “unprovoked” VTEs.

Cancer can make blood clot more easily. That’s why doctors often worry that a hidden, undiagnosed cancer is behind an unprovoked VTE, and order extensive testing such as CT scans to look for anything suspicious. Results of a study published in The New England Journal of Medicine (NEJM) suggest that these searches are usually fruitless — and costly.

Less may be more

For the NEJM study, Canadian researchers randomly assigned 854 patients with unprovoked VTEs to one of two groups.

Half had the usual tests done for people with unprovoked VTEs. These include:

  • a complete history and physical exam
  • routine blood work
  • a chest x-ray
  • sex- and age-appropriate cancer screenings.

The other half underwent comprehensive testing to look for hidden cancer. This included all of the “standard” tests plus enhanced CT scans of the abdomen and pelvis. Not only are these tests expensive, they expose people to radiation — and this exposure almost always turns out to be unnecessary.

Only 4% of the 854 people in the study were diagnosed with a new cancer during the 12 months after the clot appeared. And there was only a 1% chance of missing a hidden cancer with standard testing, as opposed to comprehensive testing.

An unprovoked VTE can be frightening, especially for people who have heard about possible links between VTEs and cancer. These results provide added reassurance that the risk of a hidden cancer is very low. And doing additional imaging to hunt for one just adds cost and radiation exposure without health benefit.

Preventing VTEs

Some VTEs clearly happen “out of the blue.” Others may be preventable. Here are some things you can do to prevent both provoked and unprovoked VTEs:

  • Stay active.
  • Get up from your desk, couch, or chair and take short walks as often as you can.
  • When sitting, move your feet up and down often to squeeze your calf muscles. This is especially important when sitting for a long time, as you might during an intercontinental flight or a long bus, train, or car ride.
  • Get your weight into the healthy range and keep it there.
  • Don’t smoke.
  • Drink plenty of water, especially when travelling long distances.

If you are admitted to the hospital or have surgery, ask your doctor about preventive treatment with blood thinners or leg “compressors.”

Related Information: Harvard Health Letter


  1. peter luken

    Prevention of VTE starts with a good diet, no flour, processed sugar, and vegetable oil.

  2. getbalancedhealth

    Nice Blog.

  3. Rie Gvas

    Indeed, life is full of surprises. Anything could happen in a snap. The prevention tips are really helpful everyday checklist especially for us who’s job requires prolonged sitting. Thanks!

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