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Cholesterol and lipids Archive

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Inherited high cholesterol: Too often overlooked

People with an inherited form of high cholesterol, known as familial hypercholesterolemia, may be both underdiagnosed and undertreated for the condition, which can cause heart attacks and stroke at an early age.

LDL cholesterol: Low, lower, and lower still

The overall message on "bad" LDL cholesterol is much the same as it has been: Lower is better and how low your level should be depends on your cardiovascular risk factors.

But the standard for what low LDL means keeps on getting lower. While  an LDL level under 70 is still the usual goal for people at the highest risk for cardiovascular disease perhaps that is still too high.

Does it matter how you lower your cholesterol?

Certain cholesterol-lowering medications—namely, ezetimibe (Zetia) and drugs known as bile acid binders—also appear to be effective at lowering cholesterol and reducing the risk of serious cardiovascular events. 

HDL cholesterol: How much is enough?

Research suggests that raising good cholesterol beyond a certain point doesn't offer any extra benefit for the heart.


Image: designer491/Thinkstock

When it comes to cholesterol, it's mostly about the numbers. You want less of the "bad" low-density lipoprotein (LDL) cholesterol and more of the "good" high-density lipoprotein (HDL) kind. This combination is often associated with a lower risk of cardiovascular disease. Sounds simple—and it is, for the most part. But while most attention is spent on driving down bad LDL, you still have to keep your eyes on the good HDL, as some research suggests that after a certain threshold, higher levels don't offer extra protection.

The role of cholesterol

Balancing act

One reason higher HDL may not always be effective is that it needs help to do its job. Another study found that HDL's protective role depends in part on the levels of both LDL and triglycerides (another type of blood fat that helps make up your total cholesterol).

The research, published online May 10, 2016, by Circulation: Cardiovascular Quality and Outcomes, analyzed data over 25 years on about 3,500 people. Researchers looked at people with both low and high HDL levels and those with normal and high levels of LDL and triglycerides.

They found that for optimal protection against cardiovascular disease, there needs to be a balance among all three. Higher HDL (40 mg/dL or higher) helped to reduce cardiovascular disease only when LDL and triglycerides were low (100 mg/dL or less). When LDL and triglycerides rose above 100 mg/dL or 150 mg/DL, respectively, higher HDL had no effect.

The ideal numbers

Fasting before a cholesterol test

Fasting for eight to 12 hours before a cholesterol test doesn’t seem to be necessary. But for now, people should continue to follow their physicians’ advice on this matter.

Your blood work, on the edge of normal

What to do when routine test results are at the high or low end of the acceptable range.


Catching early changes in blood work may help prevent chronic disease, such as diabetes. 
Image: Ca-ssis/Thinkstock

As a smart medical consumer, you know it's important to look over the results of your routine blood work, even when the numbers are all within the normal range. But what if you notice that some results are at the high or low end of that range? Should you be concerned about this?

Drink more water to cut calories, fat, and sugar?

Increasing daily water intake by one, two, or three cups daily can help reduce total calorie intake and lower a person’s intake of saturated fat, sugar, sodium, and cholesterol.

Dietary supplements for cholesterol: Are any worth a try?

Various herbs and other supplements have been touted for their ability to improve cholesterol levels. Here's what the research shows — and doesn't show — about some of the best-known products.

Hawthorne. The leaves, berries, and flowers of this plant are used to make medicine that was traditionally used to treat cardiovascular diseases. It may lower cholesterol by increasing the excretion of bile and decreasing the body's production of cholesterol. Verdict: It may possibly help.

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