Alzheimer's Archive

Listening to music or playing an instrument engages multiple parts of your brain — and can help your mood and memory.

Music has the ability to soothe, energize, and even to improve your memory. And tapping into its power is as simple as turning on your radio.

Whether your choice is jazz, classical, rock 'n' roll, or hip-hop, music has unique effects on the brain, says Dr. Andrew Budson, a lecturer in neurology at Harvard Medical School and chief of cognitive and behavioral neurology at the VA Boston Healthcare System. And you can reap benefits whether you are playing a musical instrument or just kicking back and listening to some tunes.

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Plants are loaded with naturally occurring chemicals that appear to help health. And high, long-term intakes of certain kinds of plant chemicals called flavonoids are associated with a reduced risk for developing dementia, according to a study published online April 22, 2020, by The American Journal of Clinical Nutrition. Researchers evaluated the health information of 2,800 dementia-free people (average age 59) who periodically underwent physical exams, had lab tests, and answered diet questionnaires. After 20 years, people who had reported the highest flavonoid intake were about 40% less likely to develop dementia, compared with people who'd reported the lowest intake. There are many different types of flavonoids; those with the greatest link to lower dementia risk came from tea, apples, pears, blueberries, and strawberries. A high intake was about the same as having 7.5 cups of berries, eight apples or pears, and 19 cups of tea per month. A low intake was about the same as having no berries or tea and less than two apples per month. The study was observational and doesn't prove that high flavonoid intake protected people from developing dementia. But researchers say other evidence suggests flavonoids may ward off brain inflammation and protect brain cells.

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Research we're watching

Could a single blood test one day enable doctors to diagnose Alzheimer's disease? Researchers writing in the March 2 issue of Nature Medicine say they've made advances in this area. The blood test they developed measures the concentration of pTau181 — a form of the tau protein associated with brain changes in Alzheimer's disease — in the body's blood plasma. They used the test on samples collected from more than 400 people who were part of an ongoing -memory study.

The researchers found that the blood test was able to accurately detect which patients had Alzheimer's, which were healthy, and which had a different type of dementia caused by a neurodegenerative disease. Today, doctors typically diagnose Alzheimer's using a series of tests designed to rule out other causes, but the process is time-consuming and costly. The researchers are now aiming to refine the test further, in hopes that it will someday make it easier to detect Alzheimer's at an early stage, when the disease may be easier to treat.

If you or someone else suspects early signs of memory loss, here's how you can find out if there's a problem.

There's no cure for dementia, and you cannot substantially reverse its effects, but there are ways to possibly slow its progression. But first, you need to know if you — or a loved one — may have a memory disorder. "Unfortunately, there is not one single test that confirms dementia while you are alive," says Dr. Julie Brody Magid, clinical director of the Harvard-affiliated McLean Hospital Memory Disorders Assessment Clinic. "The testing process is multilayered and takes many things into consideration. Going through this evaluation may help identify memory problems before they get worse."

Know the symptoms

Symptoms of dementia include memory loss, problem-solving difficulties, and language issues. Behavior and emotions also can be affected. Symptoms are often subtle early on, and then get progressively worse. They can increasingly interfere with daily life tasks, like remembering to attend appointments, take medication, or pay bills. People also may have trouble preparing meals or driving safely.

In the journals

Older adults with a healthy weight but a large waistline could have a higher risk of developing dementia, according to a recent study.

Weight gain and obesity are known risk factors for dementia, and body mass index (BMI) is often used to estimate excess body fat. (BMI is a measure that takes into account both weight and height.)

When people with dementia start exhibiting agitated behaviors, doctors often prescribe medications, but these have risks of serious side effects. A new study found that nondrug interventions were more effective than medications in reducing agitation.

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We've reported before that heavy drinking is tied to an increased risk for developing dementia. A Harvard-led study published online Sept. 27, 2019, by JAMA Network Open suggests that the risk is even worse if you have mild cognitive impairment (MCI). Researchers analyzed the data of more than 3,000 dementia-free adults (average age 78, some with MCI) who reported their alcohol use and underwent psychological testing for six years. People with MCI who drank heavily (more than 14 drinks per week) had a 72% higher risk for dementia than people who drank less than one drink per week. However, people without MCI who drank moderately (seven to 14 drinks per week) didn't appear to have an increased risk for dementia, and even seemed to have a 37% lower risk for dementia compared with people who consumed less than one drink per week. The bottom line: "Our results suggest that moderation is the healthiest approach if you drink. And if you have mild cognitive impairment, you may want to reconsider drinking alcohol at all," says Dr. Kenneth Mukamal, a study author and researcher with the Harvard T.H. Chan School of Public Health.

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Half of people who live to 85 will develop Alzheimer’s disease — a disturbing statistic. But research into a family in South America has revealed a gene mutation that appears to afford protection, and may lead to a way to treat or possibly even prevent the disease.

In the journals

A new study found that a simple blood test can detect beta-amyloid protein buildup in a person's brain years before Alzheimer's disease symptoms appear. The results were published online Aug. 1, 2019, by the journal Neurology.

High amounts of beta-amyloid can clump together and form plaques on the brain, which is strongly associated with Alzheimer's disease. Other research has found that amyloid plaques can appear as early as 20 years before the first sign of Alzheimer's symptoms, such as cognitive decline and memory loss.

But some experts say limitations of the study raise questions about the results.

Could one of your regular pills raise your risk of dementia? A study published online June 24 by JAMA Internal Medicine found that people over age 55 who took a daily dose of certain common drugs for approximately three years had a 50% higher risk of developing dementia.

The medicines in question are in a category known as anticholinergics, which are used to treat conditions as diverse as depression, urinary incontinence, allergies, and Parkinson's disease. The study's authors say the findings should prompt doctors to use caution or potentially even avoid prescribing certain medications to people over age 45 on a long-term basis if there are other options available.