Alzheimer's Disease Archive

Many older adults enjoy "brain games" like crosswords, chess, and computer games. But can they help improve memory?

If you are like many adults, you enjoy a good crossword, a weekly card game, or even the latest addictive phone app game. You probably even relish the mental boost they provide.

But do these types of brain games help with brain health, especially for protecting against memory loss? Well, it's complicated.

But some experts say limitations of the study raise questions about the results.

Could one of your regular pills raise your risk of dementia? A study published online June 24 by JAMA Internal Medicine found that people over age 55 who took a daily dose of certain common drugs for approximately three years had a 50% higher risk of developing dementia.

The medicines in question are in a category known as anticholinergics, which are used to treat conditions as diverse as depression, urinary incontinence, allergies, and Parkinson's disease. The study's authors say the findings should prompt doctors to use caution or potentially even avoid prescribing certain medications to people over age 45 on a long-term basis if there are other options available.

Ask the doctors

Q. I've had endometriosis since I was in my 30s. I'm now approaching menopause. Will my symptoms get better or even go away after menopause?

A. Possibly, but not always. Endometriosis is a condition in which tissue that resembles the tissue that lines the uterus, called endometrial tissue, grows in other locations inside the body. Typically, it grows on structures and organs in the pelvis, such as the ovaries, fallopian tubes, bladder, or bowels. When a woman menstruates, this tissue behaves like the lining of the uterus and bleeds. But because this blood has no way to exit the body, it pools inside. This leads to pain, inflammation, and scarring.

Research we're watching

Can emotional stress harm your bones? A new study found an association between stressful social relationships and bone problems in women. The study, which was published online July 9 by the Journal of Epidemiology & Community Health, found that women who reported high levels of social stress had lower bone density six years later. The study looked at more than 11,000 postmenopausal women. At the time of enrollment, the women filled out a questionnaire that asked them to rate their social stress levels and had their bone density measured both at enrollment and six years later at a follow-up appointment. Women who had reported high levels of stress at the initial interview showed a bigger decline in bone density at the follow-up compared with women who'd initially reported lower stress levels. This was true even after the researchers adjusted for other factors that may affect bone health, such as age, weight, smoking, alcohol use, and education, among others. The authors speculated that stress may harm bone health because stress leads to higher blood cortisol levels, a well-established reason for lower bone density. Further study is needed to understand and confirm the results.

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Some men with an enlarged prostate gland (benign prostatic hyperplasia, or BPH for short) eventually start to experience urinary incontinence, the involuntary discharge of urine. The incontinence can be related to overactive bladder, one of the changes in bladder function caused by BPH.

Normally, the brain says "time to go" when your bladder is only partially full. That gives you a fair warning to find a place to relieve yourself. When you decide to let go, a valve called the urinary sphincter opens to allow the bladder to drain. Muscles in the bladder wall squeeze inward to empty the storage tank.

Nerve damage might be causing everything from low blood pressure to gastrointestinal distress without your knowing it.

Doctors have long known peripheral neuropathy as a nerve condition that causes reduced sensation, tingling, weakness, or pain in the feet and hands. But those symptoms may be just the tip of the iceberg. Doctors are now learning that neuropathy can cause many more problems.

What is peripheral neuropathy?

Peripheral neuropathy refers to damage to the peripheral nerves throughout the body. These nerves carry messages to and from the brain.

In the journals

Gingivitis (gum disease) has been linked to a higher risk of heart disease, but a recent study says that the bacteria that cause gingivitis also may be connected to Alzheimer's disease. The study was published Jan. 23, 2019, in Science Advances.

Scientists have previously found that this species of bacteria, called Porphyromonas gingivalis, can move from the mouth to the brain. Once in the brain, the bacteria release enzymes called gingipains that can destroy nerve cells, which in turn can lead to memory loss and eventually Alzheimer's.