Vitamins, minerals & supplements Archive

Early detection and proper use of eye drops are essential to preventing vision loss.

Glaucoma is a leading cause of irreversible blindness and is more common with aging. The condition affects peripheral vision at first, but eventually becomes more widespread. Treatment with daily eye drops helps to slow the process, but it's best to start early. "Glaucoma tends to be like a snowball," says Dr. Brian Song, a glaucoma specialist at Harvard-affiliated Massachusetts Eye and Ear Infirmary. "It's easier to control it early than if you wait for it to build momentum."

Q. I've been taking dabigatran (Pradaxa) for atrial fibrillation for a few years and haven't had any problems. But I've seen ads on television suggesting that this drug and others like it aren't safe. What's your advice?

A. Known as novel oral anticoagulants, these drugs make the blood less likely to clot, which helps prevent strokes. Others in the class include rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa). They work as well as the older anti-clotting drug warfarin (Coumadin) but don't require frequent testing for clotting function and are less likely to interact with food and other drugs.

Drinking sodas and other beverages sweetened with high-fructose corn syrup may boost levels of harmful LDL cholesterol and triglycerides in your blood, according to a study in the June 2015 American Journal of Clinical Nutrition.

Researchers assigned 85 healthy adults to four different groups. One group drank beverages containing the artificial sweetener aspartame, while the others drank beverages sweetened with various percentages (10%, 17.5%, and 25%) of high-fructose corn syrup. After two weeks, LDL cholesterol levels held steady in people who drank aspartame-sweetened drinks. But among those who drank beverages with high-fructose corn syrup, LDL cholesterol rose in tandem with the percentage of sweetener.

By Anne Fabiny, M.D., Editor in Chief

Every so often, medical professional organizations issue new guidelines for treating diseases, based on an accumulation of new evidence. In 2013 the American College of Cardiology and American Heart Association issued a guideline on treating blood cholesterol to reduce atherosclerotic cardiovascular disease (ASCVD) risk, using a new risk calculator (online at health.harvard.edu/heartrisk) to estimate a person's risk of developing ASCVD over the next 10 years. The guideline created a controversy because using the new risk calculator gives everyone over 75 a risk score of at least 7.5%—the threshold for prescribing statins to prevent heart disease in younger people. By that measure, everyone over the age of 75 should be on a statin!

A healthy person needs 30 to 50 ounces of fluid per day.

More evidence that plant-based diets can help you stay healthy.

In particular, nuts and peanuts are getting attention for their heart benefits. A study published in JAMA Internal Medicine on March 2, 2015, found that among 72,000 Americans in the southern United States and 135,000 people in China, eating peanuts (a legume) and nuts (such as almonds and walnuts) was associated with a reduction of 17% to 21% in the risk of dying from any cause, especially heart disease. This study was not a randomized trial, and therefore it cannot prove that a regular diet of nuts has such positive health effects. However, two previous randomized trials did find that such a diet was heart-healthy. "Nuts and peanuts are rich in unsaturated fatty acids, known for reducing inflammation, improving blood vessel function, and lowering LDL cholesterol," says Debbie Krivitsky, director of clinical nutrition at the Cardiovascular Disease Prevention Center at Harvard-affiliated Massachusetts General Hospital. The American Heart Association recommends eating four servings of unsalted, unoiled nuts per week. A serving size is a small handful (1.5 ounces) of whole nuts or 2 tablespoons of nut butter.

Image: Thinkstock

Daily aspirin use has increased among U.S. adults, according to a survey published May 2015 in the American Journal of Preventive Medicine. The survey asked more than 2,500 people ages 45 to 75 about their current aspirin use. The overall use was 52%, up from 41% in a similar survey in 2004. The most common reasons for taking daily aspirin were prevention of heart attack and stroke. Eighteen percent of aspirin users cited cancer prevention as their reason for taking aspirin. And while most users said they'd talked to their doctor before starting aspirin therapy, 25% of the respondents had not. That finding is troubling, since aspirin is a blood thinner. "Aspirin can increase the risk of bleeding in the brain or elsewhere in the body. This risk might be justified if there is a good reason for aspirin use, but might be entirely unjustifiable if not. That is why I always recommend discussing any medication or supplement use with one's primary care provider," says Dr. Natalia Rost, associate professor of neurology at Harvard Medical School. 

Image: Thinkstock

Women are at greater risk for dementia. Joining clinical trials can help to speed the development of promising drugs.

A study published online April 13, 2015, in JAMA Internal Medicine indicates that a single infusion of the bisphosphonate drug zoledronate (Reclast) can be used to increase bone density in women who can't take oral versions of bisphosphonates. Taking an oral bisphosphonate like alendronate (Fosamax) is effective in building bone for women with osteoporosis, but it requires a commitment—taking the drug on an empty stomach and remaining upright for 30 minutes afterward. Because this may not be practical for women in assisted living facilities, they often aren't given bone-building drugs, even though their risk of hip fracture is eight to nine times that of women living at home.

The researchers studied 181 women with osteoporosis residing in assisted living facilities. The average age was 85. The women were randomly assigned to one of two treatments—1,200 milligrams of calcium and 800 IU of vitamin D daily as supplements plus a single intravenous infusion of zoledronate or the same daily doses of the supplements alone.