Stress Archive

By the time memory loss shows up, the disease is well under way. Researchers are finding ways that may reveal brain changes sooner.

For a long time, memory loss was seen as the telltale sign of Alzheimer's disease. While this is certainly the most common symptom, it may not be the best way to identify the disease in its early stages.

"A major problem of Alzheimer's diagnosis, and ultimately effective treatment, is that by the time the first clinical symptoms appear, irreversible damage to the brain has already occurred," says Dr. Seth Gale, a neurologist with Harvard-affiliated Brigham and Women's Hospital. "It is now believed that Alzheimer's-related changes begin in the brain at least a decade before any symptoms emerge."

A discussion with your doctor may minimize your chance of becoming dependent on or addicted to these powerful painkillers.

Opioid misuse is now one of most important health problems in the United States, rivaling smoking as a cause of death. Although news reports tend to focus on an opioid crisis among the young, the opioid epidemic is increasingly affecting older people as well. In fact, the rates of hospitalization for opioid overdoses among Medicare recipients quintupled from 1993 through 2012. Although older people are still less likely than younger ones to become addicted or succumb to opioid overdoses, they are more likely to suffer side effects from extended opioid use, including memory and cognition problems and falls.

"Opioid use and pain management is something we deal with constantly," says Dr. Michael L. Barnett, assistant professor of health policy at the Harvard T.H. Chan School of Public Health. According to a report from the U.S. Department of Health and Human Services, nearly one-third of Medicare beneficiaries received at least one prescription for opioids in 2015, and those who did got an average of five such prescriptions or refills. Dr. Barnett and a team of his colleagues decided to investigate how Medicare recipients get opioid prescriptions in the first place.

There is growing evidence that the placebo effect is at work in most successful medical therapies.

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When you were a child, your mother or grandmother might have used a home remedy that made you feel better, especially when it was delivered with a soothing hand on the forehead or a kiss on the cheek. Perhaps she assured you that a cup of warm milk would help you fall asleep, and you found that it did.

Unbeknownst to you — or her — she was probably harnessing the placebo effect, loosely defined as a favorable response to a medical intervention that doesn't have a direct physiological effect. Although you may have learned later in life that there isn't much scientific evidence to support the practice, you may still sleep better after a cup of warm milk at bedtime.

Research suggests that moving out of your comfort zone is the key to staying mentally and physically young.

Finding role models who are older than we are gets more difficult as we age. But in the last few years, medical science has identified a new group we can aspire to join — the super-agers. The term refers to people in their 70s and 80s who have the mental or physical capability of their decades-younger counterparts.

What makes a cognitive super-ager?

Dr. Bradford Dickerson, a neurologist at Harvard-affiliated Massachusetts General Hospital and his colleagues have been studying super-agers for several years. Their results suggest that embracing new mental challenges may be the key to preserving both brain tissue and brain function.

Don't assume age is to blame for changes in memory, attention, and decision making.

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Depression has a way of sucking the joy and meaning from life. Chronic feelings of hopelessness, apathy, or despair are part of the condition. It may also bring physical symptoms, such as weight loss, sleep disturbance, fatigue, and aches and pains. But depression can be sneaky, causing subtle changes in thinking skills that you may not attribute to the condition. "Very often, one of the first signs of depression in people ages 70 or older is a change in thinking," says Dr. Helen Farrell, a psychiatrist with Harvard-affiliated Beth Israel Deaconess Medical Center.

What's the connection?

Depression may involve the interruption or reduction of chemical messengers in the brain called neurotransmitters, such as serotonin, dopamine, and norepinephrine. These chemical changes may be the cause of your depression (if the brain systems that regulate them go awry), or they may result from other depression triggers, such as the following:

As doctors acknowledge the role that they have played in the current opioid crisis, they, along with hospitals, medical schools, and other members of the medical community have worked to address the issue on several fronts, including instituting prescribing guidelines and offering continuing education to prescribers.