Diabetes Archive

Research we're watching

A unique diabetes drug shows heart-related benefits in people with diabetes who also have recently worsening heart failure or kidney disease, according to two new studies.

The drug, sotagliflozin (Zynquista), belongs to a class of drugs called SGLT2 inhibitors, which cause the kidneys to release more sugar into the urine. The drug is also an SGLT1 inhibitor, meaning it decreases sugar absorption in the intestines. This dual action lowers high blood sugar, the hallmark of diabetes. In people with kidney disease, sotagliflozin lowered the total number of deaths from cardiovascular disease and hospitalizations and urgent visits for heart failure by about 26% compared with a placebo. In a second study, which included people with recently worsening heart failure, those taking the drug had a 33% decrease in those same heart-related measures compared with a placebo.

Research we're watching

Doing vigorous exercise for just 12 minutes triggers changes in blood levels of substances linked to cardiovascular health, new research finds.

The study used data from 411 middle-aged adults from the Framingham Heart Study. Researchers measured levels of 588 substances involved in metabolism (metabolites) in the volunteers' blood before and immediately after 12 minutes of vigorous exercise on an exercise bike.

Learn what will and won't increase blood sugar levels and put your health in jeopardy.

It's essential to keep your blood sugar from spiking (rising suddenly), whether you're healthy or you're among the 122 million Americans who have diabetes or prediabetes. But with all the conflicting advice in circulation, it can be hard to figure out what foods and habits you need to avoid.

Bogus claims

On the Internet you'll find many reports of factors that purportedly increase blood sugar. Here are a few claims that you should know about because they just don't hold up.

News briefs

Drinking coffee or green tea is associated with many health benefits, such as better cardiovascular health, lower inflammation levels, and a reduced risk for developing chronic disease. Now, a study published online Oct. 20, 2020, by BMJ Open Diabetes Research & Care suggests tea and coffee consumption are also linked to a reduced risk for early death among people with diabetes. Researchers evaluated the health and self-reported lifestyle habits — including diet — of about 5,000 people in Japan over five years. Compared with people who didn't drink any coffee or green tea, people who drank the most had much lower risks of premature death from any cause: about 40% lower for people who drank either two cups of coffee or four cups of tea per day; and 63% lower for people who drank both four cups of tea plus two cups of coffee per day. The study is only observational and doesn't prove that the drinks keep people alive longer. But we know coffee and tea contain powerful plant compounds with anti-inflammatory and antioxidant properties that are good for health.

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On call

Q. I eat plenty of fruits and vegetables, but are whole grains also important?

A. Fruits and vegetables seem to get top billing on the healthy food list, but I put whole grains right up there. There are two types of grain: whole and refined. All grains grow as kernels, and each kernel has three layers:

News briefs

Bisphenol A (BPA), used to make some plastics and epoxy resins, has made headlines for years because of its association with an increased risk for obesity, diabetes, high blood pressure, and cardiovascular disease in humans. Now high levels of BPA exposure have been linked to an increased risk for premature death from any cause, according to a study published online Aug. 17, 2020, by JAMA Network Open. Scientists analyzed the survival rates of about 3,900 people who provided health information and urine samples and were then followed for 10 years. People with the highest levels of BPA in their urine had a 51% higher risk of dying during that period, primarily from heart disease, compared with people who had the lowest levels of BPA. The findings don't prove that BPA caused premature death, but they add to concerns about BPA's potential toxicity. BPA and related chemicals are found in many products, such as water bottles, cups, dental sealants, paper receipts, and the linings of food and beverage cans and pipes, so it's hard to avoid them. Simple precautions include relying less on canned foods and more on fresh foods; avoiding plastics with a 3 or 7 recycling label; microwaving food in glass or ceramic containers, not plastic; and looking for BPA-free products.

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Ask the doctors

Q. I'm trying to eat less sugar. Can you offer any tips that can help?

A. First, congratulations. Cutting down your consumption of sugar can help protect your health in the long term. Sugar-heavy diets have been linked to health conditions, including obesity, diabetes, and heart disease. Most Americans eat far too much sugar. A U.S. government health and diet survey from 2015–16 found that the average American eats about 17 teaspoons of sugar a day. The Dietary Guidelines for Americans recommend eating no more than the equivalent of 12 teaspoons of sugar a day, and the American Heart Association suggests no more than the equivalent of six teaspoons per day. To cut down on your sugar consumption, your first goal should be to focus on incorporating more whole, unprocessed foods into your daily diet. Eating more of these foods can crowd out processed sources of added sugars in your diet.

In the journals

Scientists continue to explore the right balance of carbohydrates and fat in people's diets. But for overweight or obese older adults, a recent study found that a low-carbohydrate, high-fat diet might offer special health benefits. The results were published online Aug. 12, 2020, by Nutrition and Metabolism.

Researchers asked 40 obese adults, ages 60 to 75, to follow an eight-week diet in which 10% of calories came from carbs, 25% from protein, and 65% from fat. Carb sources included leafy greens, non-starchy vegetables, some fruit, and high-fiber grains. Protein intake consisted of eggs, fish, pork, and poultry. Fat-containing foods included olive oil, coconut oil, nut oils, nut butter, cheese, coconut milk, and avocados.

When diet and exercise are not enough for a person with diabetes to manage their blood sugar, one or more medications may be needed. Adding a second medication can offer additional benefits beyond blood sugar control, but the benefits and risks of these newer classes of drugs must be weighed for each person.