Autoimmune diseases Archive

Autoimmune disorders that may involve skin symptoms include psoriasis, lupus, scleroderma, dermatomyositis, vitiligo, bullous pemphigoid, alopecia areata, lichen planus, autoimmune thyroid disease, celiac disease, rheumatoid arthritis, and sarcoidosis.

Rheumatoid arthritis (RA) affects two to three times as many women as men. Scientists are uncovering RA's potential genetic and hormonal underpinnings, which point to potential reasons why women are more vulnerable. The newest treatments, called Janus kinase (JAK) inhibitors, resulted from research that has teased out delicate differences in immune system pathways. They block numerous proteins that ramp up inflammation fundamental to RA. The wide array of drug options now available for RA help doctors personalize therapies to each patient.

Some people have poor circulation, but if your fingers pale and go numb when exposed to quick changes in temperature, it could be Raynaud's phenomenon, a different kind of circulation problem. Generally, avoiding sudden exposure to cold and other factors that cause blood vessels to constrict, and being prepared with gloves and extra layers of clothing, helps.

People with autoimmune diseases may be up to three times more likely to develop cardiovascular disease than people without an autoimmune disease. Among the most common autoimmune diseases are rheumatoid arthritis, psoriasis, and lupus. Awareness of this elevated risk is especially important because autoimmune disease typically strikes when people are in their 20s or 30s. In turn, heart problems may develop up to a decade earlier than in people without an autoimmune disease. A calcium scan, which detects early signs of atherosclerosis, can help assess a person's risk and guide treatment advice.

Genes that helped people survive during the time of the Black Death are more likely to be found in people with autoimmune diseases alive today. Does this tell scientists anything about what surviving the COVID-19 pandemic might mean for the world's population?