Alzheimer's Disease Archive

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Q. My feet tingle or feel numb like they are asleep at times, mostly when I am in bed or with my legs elevated. What causes that?

A. The symptoms you describe may be related to peripheral neuropathy, which is nerve damage that affects multiple nerves leading out from the spinal cord to the arms and legs. Symptoms are often equal in both feet. If only one foot, or part of a foot, is affected, this suggests compression of an individual nerve.

For people with fibromyalgia, pain is a part of daily life, and exercising is probably not something they feel like doing. But experts say it’s one of the most effective strategies to help manage the condition. So what’s the best approach to getting started?

The trials and challenges of this year are weighing heavily on many people, but attempting to employ positive psychology to put personal struggles in context, and accepting the ups and downs life brings, can ultimately increase positive feelings and provide perspective.

We don't yet have a vaccine to prevent COVID-19, but it's still important to get your regularly scheduled shots.

You're not alone if you're avoiding doctor visits because of concerns about COVID-19. But forgoing medical care means you may be skipping needed vaccinations. "That's a huge problem already. Possibly over a hundred million people the world over have missed their vaccinations because of the pandemic," says Dr. Shiv Pillai, an immunologist and professor of medicine at Harvard Medical School.

Going without vaccinations may increase your risk for illness, such as influenza. "We still are just as vulnerable to infection, and we need vaccines to be protected; COVID-19 doesn't change that," says Harvard Health Letter editor in chief Dr. Anthony Komaroff.

News briefs

Probiotic supplements containing helpful bacteria and yeast are marketed as a way to maintain a diverse mix of healthy gut microbes. Now, a review published online July 6, 2020, by BMJ Nutrition, Prevention & Health suggests that probiotic supplements may help relieve depression symptoms. Scientists evaluated seven clinical trials from the past 15 years, which tested a total of 12 different strains of helpful bacteria. One trial in the review tested a "prebiotic," a type of plant fiber that provides food for gut bacteria. Scientists concluded that 11 of these probiotics, either alone or combined with prebiotics, were potentially useful for relieving symptoms of depression, perhaps by reducing inflammation that could affect brain function. The studies were small and short-term, but taken together, they suggest a gut-based approach to maintaining emotional well-being is worth pursuing. In the meantime, talk therapy, exercise, and medications remain the most effective approaches to treat depression. To support your gut health without expensive probiotic supplements, enjoy foods that naturally contain probiotics, such as yogurt, kefir, and sauerkraut. The prebiotic powers of whole grains also may support a healthy gut.

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People who regularly worried about the future and dwelled on the past saw larger drops in cognition and had more harmful brain proteins than those who didn't.

Chronic worrying or ruminating could be bad for your brain. A study published online June 7, 2020, by Alzheimer's & Dementia linked these negative thinking patterns to brain changes that could be associated with Alzheimer's disease.

Study authors found that older adults who regularly engaged in what the authors called repetitive negative thinking were more likely to experience cognitive decline, including memory problems, than those who didn't. They also had higher levels of the proteins beta-amyloid and tau in their brains. The accumulation of these proteins, which create damaging clumps known as plaques and tangles in the brain, is a hallmark of Alzheimer's that begins in the earliest stages of the disease — even before an individual experiences visible symptoms of dementia.

Ask the doctors

Q. I have hemorrhoids. Could this increase my risk of colon cancer?

A. In short, no. Hemorrhoids don't cause or increase your risk for colon or rectal cancer. However, the two conditions may be mistaken for one another because they can produce similar symptoms, such as rectal bleeding, itching, and pain.

With the introduction of benzodiazepines such as chlordiazepoxide (Librium) and diazepam (Valium) in the early 1960s, a new era in the treatment of insomnia and anxiety began. The benzodiazepines were more effective and far safer than the older drugs — barbiturates, meprobamate, and glutethimide — that had been prescribed for these purposes. For many years, benzodiazepines continued to be the most popular prescription tranquilizers and sedatives. Since the mid-1980s, new alternatives have been assuming some of these roles, but benzodiazepines are not about to leave the stage.

More than a dozen benzodiazepines are available by prescription. Benzodiazepines have a common basic chemical structure, and they all increase activity at receptors for the neurotransmitter gamma-aminobutyric acid (GABA). This transmitter inhibits the activity of neurons, slowing down the brain and nervous system. Benzodiazepines differ mainly in how quickly they are absorbed, how long their effects last, and how long they take to leave the body.

The condition tends to strike many older adults, but there are ways to counter its paralyzing effects.

More and more, do you find yourself fighting feelings of worry? Do you feel increasingly anxious and tense? Do you obsess about things that may or may not happen? If so, you may be one of the millions who suffer from anxiety.

Anxiety can develop from many uncontrollable factors, such as genetics, personality, and life events, but the main issue for many older men is that they have too much time on their hands, according to Dr. Cornelia Cremens, a psychiatrist with Harvard-affiliated Massachusetts General Hospital.

Living with the pain and fatigue of fibromyalgia is a challenge faced by millions of people. Finding a doctor who understands the condition and how to treat it can be hard, but knowing the facts about your condition and what questions to ask can help you find the right doctor.