Long-term use of proton-pump inhibitors (PPIs) carries some risks. PPIs can interfere with the body’s absorption of vitamin B12 from food. PPIs can also interfere with calcium absorption in the body, which in turn means weaker bones. Using the medications for more than a year or taking higher doses of PPIs increases the chances of a fracture. Using PPIs may also make one susceptible to an infection with Clostridium difficile (C. difficile) bacteria.
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