Mind & Mood Archive

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Chronic inflammation in midlife linked to brain decline later

News briefs

You've probably heard about tests to measure chemicals in the blood that indicate chronic inflammation in the body. They are sometimes used to estimate risk for heart disease. But what about using these kinds of biomarkers to gauge your risk for declining brain health? A study published Nov. 1, 2017, in Neurology found that having certain inflammatory markers in midlife was associated with brain shrinkage and poor memory in older age.

Researchers measured five inflammation biomarkers in about 1,600 middle-aged people and gave them brain scans and a memory test about 25 years later. Compared with people with no elevated inflammation markers, people with high levels of three or more biomarkers scored lower on the memory test and had about 5% shrinkage in the hippocampus and other parts of the brain associated with Alzheimer's disease.

When worry becomes a problem

Feeling afraid about life issues is common as you age, but if it takes over your life, you may have generalized anxiety disorder (GAD).


 Image: © pixelheadphoto/Thinkstock

Everyone feels afraid or worried at times, but if these feelings begin to take over your life, then you may have crossed over into generalized anxiety disorder (GAD), which is the most common anxiety disorder among older adults, according to the Anxiety and Depression Association of America (ADAA).

"The issue with many older men is they often just endure the discomfort of GAD, or think it's normal, and do not talk about the problem," says Dr. David Mischoulon, director of the Depression Clinical and Research Program at -Harvard-affiliated Massachusetts General Hospital. "However, left alone to manifest, GAD may lead to serious health problems, such as high blood pressure, depression, and addictive behavior like excessive drinking."

Exercise is an effective stress-buster

If exercise were available as a pill, experts say, everyone would be taking it. One reason is that exercise is very good at defusing stress. If you exercise — especially right when the stress response is triggered — you burn off stress hormones just as nature intended, instead of letting them pile up.

What's more, just about any form of motion on a regular basis helps relieve pent-up tension. Rhythmic, repetitive movements, such as walking, running, swimming, bicycling, and rowing — and specific types of exercise such as yoga, tai chi, and qigong — actually elicit the relaxation response, too. Regularly engaging in these kinds of activities can help you ward off everyday stress.

Holiday for one?

Get through the season on your own by changing your perspective, creating new traditions, and reaching out to others.


  Image: © verbaska_studio/Thinkstock

The holidays are traditionally a time for family and friends. But plenty of people find themselves alone at this time of the year, especially older adults who live by themselves, are unable to drive, or live far from grown children. "I think it's probably hardest for people who have recently lost a loved one," says Dr. Suzanne Salamon, associate chief of gerontology at Harvard-affiliated Beth Israel Deaconess Medical Center.

Emotional impact

A number of emotions may creep in when you face holidays alone. One is pressure to make the holiday an event. "There's a feeling that it's supposed to be a celebration. That may be stressful if you have no one to celebrate with," says Dr. Elyse Park, director of behavioral health research at the Harvard-affiliated Benson-Henry Institute for Mind Body Medicine.

What to do about mild cognitive impairment

MCI can be tough to identify, but there may be ways to postpone, and possibly prevent, its impact on memory and thinking.

Everyone has the occasional bout of forgetfulness, whether it's misplacing your keys or blanking out on a name. But if these episodes become frequent or interfere with daily life, you may have mild cognitive impairment, or MCI.

MCI falls somewhere between the usual cognitive decline of normal aging and the more serious signs of dementia and Alzheimer's disease. An estimated 10% to 20% of adults older than 65 have MCI, according to the Alzheimer's Association. But this gray area of brain health is often difficult to detect.

Avoid drowsiness after holiday feasts

Ask the doctor


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Q. Is there a way to avoid feeling sleepy after a holiday meal?

A. That's an unusual question: my patients usually ask me about foods to help them sleep. But with the holidays coming, the concern often is reversed. You may be with friends and family that you see only infrequently, and you don't want to nod off during the conversation.

Ramp up your resilience!

Being resilient is a skill you can learn and sharpen, and it's never too late to give it a try.


 Image: © Ariel Skelley/Thinkstock

The ability to bounce back from stress or adversity is important throughout life, especially in our older years. That's when we face many transitions, such as health problems; job, income, and home changes; the loss of loved ones; and isolation or separation from friends, grown children, and grandchildren. How we adjust to these changes helps determine what life will look like moving forward. "Many people are living longer, and we want to make the most of these years so people can thrive," says Laura Malloy, the Successful Aging program director at the Harvard-affiliated Benson-Henry Institute for Mind Body Medicine.

The benefits of resilience

Coping with stress in a positive way is known as resilience, and it has many health benefits. It's associated with longevity, lower rates of depression, and greater satisfaction with life. "There's a sense of control, and it helps people feel more positive in general," Malloy says.

Can brain training programs actually improve memory?

On call


 Image: © Digital Vision/Thinkstock

Q. I have been seeing a lot about brain training programs to improve memory. Do they really work?

A. Brain training programs promise to preserve cognitive abilities, but so far research has not found they can delay or prevent brain decline.

Opioid misuse rising among older adults

Research we're watching

A growing number of older adults are misusing opioids, according to a new report by the Substance Abuse and Mental Health Services Administration of the U.S. Department of Health and Human Services. The 2014 National Survey on Drug Use and Health showed that the percentage of adults ages 50 and older using heroin or misusing prescription opioids jumped from 1.1% to 2% between 2002 and 2014. In contrast, opioid use in adults ages 18 to 25 dropped from 11.5% to 8.1% over the same period.

Drug use can bring particular risks to the health and well-being of older adults because they are more likely than younger people to have other illnesses and often take medications that can interact with opioids, according Center for Substance Abuse Treatment. "These findings highlight the need for prevention programs for all ages as well as to establish improved evidence-based treatment, screening, and appropriate referral services," Dr. Kimberly Johnson, director for the Center for Substance Abuse Treatment, said in a written statement.

Putting off retirement may benefit your brain, health, and longevity

The purpose and engagement of a job you love can keep you healthy and connected.


 Image: © monkeybusinessimages/Thinkstock

While many women dream of kicking back and relaxing into retirement, there's increasing evidence that in some cases, it's better for your brain and your health to keep your nose to the grindstone a little longer.

"The research to date is mixed, but it tends toward the positive — that is, for many people, there are health benefits to working longer," says Dr. Nicole Maestas, associate professor of health care policy at Harvard Medical School.

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