Lung cancer Archive

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Regular aspirin use is associated with a reduced risk for developing colorectal cancer in older age — but you won't get the benefit if you start the therapy too late in life, according to a Harvard study published online Jan. 21, 2021, by JAMA Oncology. Researchers combined the results of two large studies involving a total of more than 94,000 people who answered health questionnaires regularly and were followed for three decades. Compared with people who didn't take aspirin, people ages 70 or older who took either 325 milligrams (mg) or 81 mg of aspirin at least twice per week had a 20% lower risk for developing colorectal cancer — but only if they had started the therapy by age 65. Starting aspirin therapy at or after age 70 was not associated with significant protection against colorectal cancer. The study was observational and does not prove whether aspirin can or cannot ward off colorectal cancer. But other observational studies have also shown an association between aspirin use and lower colorectal cancer risk. Like any medicine, aspirin isn't risk-free: regular use increases the risk for gastrointestinal bleeding. If you happen to be taking aspirin regularly for other reasons, this might be an added benefit.

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Ask the doctors

Q. I was worried about drying my nails with a lamp or light box at the nail salon because of the potential risk of cancer from the ultraviolet radiation, but my salon recently switched to LED lamps. Are they safer?

A. The light boxes used to cure polish during gel manicures, and to dry traditional nail polish, have raised some concern because — like tanning beds — they emit ultraviolet A (UVA) radiation, which is associated with a higher cancer risk. A 2014 study in JAMA Dermatology found that the level of UVA exposure associated with a gel manicure every two weeks probably isn't high enough to increase the risk of skin cancer significantly, but you are wise to be aware of the issue.

Advances in breast cancer research have led to more personalized treatments, based on subtyping and more sophisticated testing. A risk assessment test can predict that some women do not need chemotherapy but will benefit from hormone therapy, and who might benefit more from both treatments.

Can adopting a healthier diet help fight prostate cancer? That's a question men newly diagnosed with prostate cancer often ask their doctors.

Several studies have shown that in countries where men eat a typical "Western" diet containing a large amount of meat, the incidence of prostate cancer, especially aggressive prostate cancer, is higher than in countries where plant-based foods are a primary part of the diet. Unfortunately, these studies weren't designed to prove cause and effect. So for now, definitive answers about prostate cancer and diet aren't yet in — although researchers are actively studying this topic.

In the last decade, overall rates of colorectal cancer have been falling among the general population in the US. However, African Americans are more likely to develop colorectal cancer at younger ages, and to die from it. The reasons for this disparity are unclear, but they are rooted in socioeconomic and racial inequities.

News briefs

Hold off before you follow new recommendations to treat mild, persistent asthma — or at least consult your doctor first. The updated guidelines from the National Institutes of Health, published online in the December 2020 issue of The Journal of Allergy and Clinical Immunology, say it's okay for people with mild, persistent asthma to stop daily use of inhaled corticosteroids and instead use them only as needed, along with short-acting beta agonists ("rescue" medications). That's considered a major shift in guidance. But that may not be a good idea for some older adults, notes Dr. Anna Wolfson, an allergist and immunologist at Harvard-affiliated Massachusetts General Hospital. "A lot of people have a harder time with the occasional use of medications than a routine practice of daily use," she says. "And you may not want to decrease your asthma regimen during the pandemic. Poorly controlled asthma could lead to a flare or an ER visit, and perhaps an increased risk for complications if you develop COVID-19." Dr. Wolfson says there are some people who might benefit from using inhaled corticosteroids only as needed, but she urges you to speak with your doctor before changing your medication regimen.

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News briefs

The pandemic may have you feeling reluctant to seek medical treatment. But when it comes to cancer care, even a short delay in treatment may lead to deadly outcomes, according to a review of 34 studies published online Nov. 4, 2020, by BMJ. Researchers evaluated treatment delay and survival in more than a million people who had cancer of the bladder, breast, colon, rectum, lung, cervix, or head and neck. Each four-week delay in treatment — whether surgery, radiation therapy, or medication (such as chemotherapy or immunotherapy) — was associated with an increase of 6% to 8% in the likelihood of dying during the study period. Scientists say delays of up to eight weeks and 12 weeks further increased the risk of death. For example, in women who delayed breast cancer surgery by eight weeks, there was a 17% increased death risk; women who delayed surgery by 12 weeks had a 26% increase. Keep in mind, there are lots of unavoidable reasons why cancer treatment might be delayed, such as not being strong enough to undergo procedures or scheduling issues at a treatment center. But if there isn't a good reason to delay, it's best to get treatment as soon as possible.

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Many studies have explored the relationship between hair dye use and risk of cancer or cancer-related death, with conflicting findings. In a recent study, researchers analyzed survey data from over 117,000 women collected over several decades regarding hair dye use and overall cancer risk.

Screening for colorectal cancer can lower mortality, but it varies in effectiveness and is not always possible to perform, so alternatives are needed. Researchers analyzing studies found evidence for regular use of low-dose aspirin, leading the US Preventive Services Task Force to recommend it for some people.