Cancer Archive

If you're among the nearly 17 million adults in this country who's had cancer, pay extra attention to your heart health.

Thanks to advances in early detection and treatment, people with cancer are living far longer than in past decades. But cancer survivors should be aware that cancer and its treatments can compromise cardiovascular health, according to a recent study from the CDC.

Researchers studied more than 840,000 adults, including about 69,000 cancer survivors, to see how much cancer "ages" the heart. They found that adult men treated for cancer had hearts that appeared to be 8.5 years older than their actual age, while the hearts of women who survived cancer appeared to be 6.5 years older.

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Regular aspirin use is associated with a reduced risk for developing colorectal cancer in older age — but you won't get the benefit if you start the therapy too late in life, according to a Harvard study published online Jan. 21, 2021, by JAMA Oncology. Researchers combined the results of two large studies involving a total of more than 94,000 people who answered health questionnaires regularly and were followed for three decades. Compared with people who didn't take aspirin, people ages 70 or older who took either 325 milligrams (mg) or 81 mg of aspirin at least twice per week had a 20% lower risk for developing colorectal cancer — but only if they had started the therapy by age 65. Starting aspirin therapy at or after age 70 was not associated with significant protection against colorectal cancer. The study was observational and does not prove whether aspirin can or cannot ward off colorectal cancer. But other observational studies have also shown an association between aspirin use and lower colorectal cancer risk. Like any medicine, aspirin isn't risk-free: regular use increases the risk for gastrointestinal bleeding. If you happen to be taking aspirin regularly for other reasons, this might be an added benefit.

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Ask the doctors

Q. I was worried about drying my nails with a lamp or light box at the nail salon because of the potential risk of cancer from the ultraviolet radiation, but my salon recently switched to LED lamps. Are they safer?

A. The light boxes used to cure polish during gel manicures, and to dry traditional nail polish, have raised some concern because — like tanning beds — they emit ultraviolet A (UVA) radiation, which is associated with a higher cancer risk. A 2014 study in JAMA Dermatology found that the level of UVA exposure associated with a gel manicure every two weeks probably isn't high enough to increase the risk of skin cancer significantly, but you are wise to be aware of the issue.

Advances in breast cancer research have led to more personalized treatments, based on subtyping and more sophisticated testing. A risk assessment test can predict that some women do not need chemotherapy but will benefit from hormone therapy, and who might benefit more from both treatments.

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Living a healthy lifestyle may be one of the best things you can do to tame the heartburn of gastroesophageal reflux disease (GERD), suggests a research letter published online Jan. 4, 2021, by JAMA Internal Medicine. Harvard researchers analyzed the self-reported health information of about 43,000 middle-aged women who were followed for 10 years. Women who adhered to five healthy lifestyle factors, regardless of whether they took heartburn medication, appeared to prevent nearly 40% of their GERD symptoms each week. The pill-free approaches included maintaining a healthy body weight (a body mass index between 18.5 and 24.9); not smoking; getting 30 minutes daily of moderate-to-vigorous physical activity; limiting coffee, tea, or soda to no more than 2 cups per day; and eating a healthy diet. "Each one of these factors may prevent the inappropriate relaxation of the sphincter muscle between the stomach and the esophagus, helping to keep acid from refluxing up and causing heartburn. For example, carrying extra weight around the waist can push on the stomach, forcing stomach acid up into the esophagus," says Dr. Raaj S. Mehta, lead author of the study and a gastroenterology fellow at Harvard-affiliated Massachusetts General Hospital.

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Can adopting a healthier diet help fight prostate cancer? That's a question men newly diagnosed with prostate cancer often ask their doctors.

Several studies have shown that in countries where men eat a typical "Western" diet containing a large amount of meat, the incidence of prostate cancer, especially aggressive prostate cancer, is higher than in countries where plant-based foods are a primary part of the diet. Unfortunately, these studies weren't designed to prove cause and effect. So for now, definitive answers about prostate cancer and diet aren't yet in — although researchers are actively studying this topic.

In the last decade, overall rates of colorectal cancer have been falling among the general population in the US. However, African Americans are more likely to develop colorectal cancer at younger ages, and to die from it. The reasons for this disparity are unclear, but they are rooted in socioeconomic and racial inequities.

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Hold off before you follow new recommendations to treat mild, persistent asthma — or at least consult your doctor first. The updated guidelines from the National Institutes of Health, published online in the December 2020 issue of The Journal of Allergy and Clinical Immunology, say it's okay for people with mild, persistent asthma to stop daily use of inhaled corticosteroids and instead use them only as needed, along with short-acting beta agonists ("rescue" medications). That's considered a major shift in guidance. But that may not be a good idea for some older adults, notes Dr. Anna Wolfson, an allergist and immunologist at Harvard-affiliated Massachusetts General Hospital. "A lot of people have a harder time with the occasional use of medications than a routine practice of daily use," she says. "And you may not want to decrease your asthma regimen during the pandemic. Poorly controlled asthma could lead to a flare or an ER visit, and perhaps an increased risk for complications if you develop COVID-19." Dr. Wolfson says there are some people who might benefit from using inhaled corticosteroids only as needed, but she urges you to speak with your doctor before changing your medication regimen.

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