Cosmetic injections more likely to produce side effects in people with certain conditions
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- Reviewed by Robert H. Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing
People with certain chronic conditions may be significantly more likely to experience side effects after cosmetic injections with botulinum toxin (Botox, Dysport, Xeomin), according to a study published online Oct. 23, 2025, by Aesthetic Surgery Journal.
Researchers in the United Kingdom surveyed 919 adults (average age 39, 91% women) who had undergone botulinum toxin injections in their face or neck. Participants reported any chronic health conditions (physical and mental) and if they had experienced short- or long-term side effects after the injections. The researchers used statistical models to determine whether having certain medical conditions was associated with a higher chance of specific side effects.
Participants with skin diseases, type 1 diabetes, chronic migraines, or thyroid disorders were far likelier to report nausea after botulinum toxin injections compared with people who did not have those conditions. Bruising and swelling was reported more often in people with conditions such as anxiety, depression, thyroid disorders, and obesity. Lingering injection pain was more common among participants with cataracts or anxiety. People with certain underlying conditions might benefit from modified injection techniques and extra counseling and monitoring surrounding botulinum toxin injections, the study authors said.
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About the Reviewer
Robert H. Shmerling, MD, Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing
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