Healthy aging and longevity Archive

We don't yet have a vaccine to prevent COVID-19, but it's still important to get your regularly scheduled shots.

You're not alone if you're avoiding doctor visits because of concerns about COVID-19. But forgoing medical care means you may be skipping needed vaccinations. "That's a huge problem already. Possibly over a hundred million people the world over have missed their vaccinations because of the pandemic," says Dr. Shiv Pillai, an immunologist and professor of medicine at Harvard Medical School.

Going without vaccinations may increase your risk for illness, such as influenza. "We still are just as vulnerable to infection, and we need vaccines to be protected; COVID-19 doesn't change that," says Harvard Health Letter editor in chief Dr. Anthony Komaroff.

How can you protect yourself from both viruses?

With flu season here and the COVID-19 pandemic ongoing, what can people expect when these two illnesses meet?

It's anyone's guess.

"While we're in the midst of the COVID pandemic, there's a lot of uncertainty about what will happen when this collides with our yearly flu epidemic," says Dr. Mary Watson Montgomery, an infectious disease expert at Harvard-affiliated Brigham and Women's Hospital.

Research we're watching

People with prediabetes — a condition in which blood sugar is elevated but not high enough to be considered diabetes — often go undiagnosed. That may put them at higher risk of cardiovascular disease and even early death, according to an analysis of 129 studies published in the July 18, 2020, issue of The BMJ.

The analysis, which combined data on some 10 million people, found that prediabetes raised the risk of dying from cardiovascular disease by 15% and from any cause by 13% over a median follow-up period of about 10 years. The mortality risk was even higher in people with prediabetes who also had coronary artery disease: they had nearly a 40% increased risk of dying within a median follow-up period of just three years. The study authors suggest that finding and addressing more cases of prediabetes could lead to a lower risk of future cardiovascular disease.

Research we're watching

A specialized fall prevention program managed by nurses wasn't able to significantly reduce the rate of serious falls among high-risk adults over age 70, according to a study published July 9, 2020, in The New England Journal of Medicine. The STRIDE program (the name stands for Strategies to Reduce Injuries and Develop Confidence in Elders) was tested by the Patient-Centered Outcomes Research Institute and National Institutes of Health as a means of reducing falls among high-risk seniors.

Falls are a leading cause of injury in people 65 and older, with some three million adults heading to the emergency room each year with a serious injury caused by a fall. Program staff worked with individuals at least 20 months to identify and modify such risk factors as problems with walking or balance, hazards in the home that made a fall more likely, a history of low blood pressure when standing, and low vitamin D levels.

Get an approved blood pressure device and follow these steps.

Monitoring your blood pressure at home has always made good sense. Blood pressure is one of the main indicators of cardiovascular health, and taking measurements is an important way to manage chronic conditions between doctor visits.

Now, with a pandemic under way and fewer people visiting their doctors, the case for monitoring blood pressure at home has never been stronger. Home monitoring yields valuable information for you and your physician, who'll be counting on you to provide accurate blood pressure measurements when you talk on the phone or in a video chat.

News briefs

A modest uptick in the amount of fruit and vegetables you eat can help ward off type 2 diabetes, according to a study published online July 8, 2020, by The BMJ. From a much larger study involving some 340,000 people from eight European countries, scientists selected 9,754 participants who were newly diagnosed with diabetes over a decade. Researchers compared the fruit and vegetable intakes of these people to those of about 13,000 participants who remained diabetes-free during the study period. Researchers also measured blood levels of seven key plant-derived nutrients, including vitamin C and brightly colored antioxidant pigments called carotenoids. People with the highest intakes of fruit and vegetables and the highest blood levels of the plant-derived nutrients were 25% to 50% less likely to get diabetes during the study period, compared with those who ate the least of these food groups or had the lowest nutrient levels. Even better, it didn't take a whole lot of extra green, red, yellow, and orange on the plate to make a dent in diabetes risk. The equivalent of only two-thirds of a medium apple or just over one-third of a cup of mixed fruit each day offered protection.

Image: © RomoloTavani/Getty Images

In the journals

Not only can regular leg stretching help reduce cramps and muscle strains, it also may be another way to protect against heart disease and stroke. A study published online July 1, 2020, by The Journal of Physiology found that performing simple leg stretches can help improve blood flow throughout the body.

Researchers split 39 healthy people into two groups. One group didn't do any stretching. The other group performed four types of leg stretches five times a week for 12 weeks. The stretches focused on the hip, knee, and ankle. Each stretch was done for 45 seconds with a 15-second recovery. Afterward, the researchers found that the arteries in the lower legs of the stretching group had better blood flow and less stiffness. The stretching group also had lower blood pressure at the end of the study compared with their initial readings.

People who regularly worried about the future and dwelled on the past saw larger drops in cognition and had more harmful brain proteins than those who didn't.

Chronic worrying or ruminating could be bad for your brain. A study published online June 7, 2020, by Alzheimer's & Dementia linked these negative thinking patterns to brain changes that could be associated with Alzheimer's disease.

Study authors found that older adults who regularly engaged in what the authors called repetitive negative thinking were more likely to experience cognitive decline, including memory problems, than those who didn't. They also had higher levels of the proteins beta-amyloid and tau in their brains. The accumulation of these proteins, which create damaging clumps known as plaques and tangles in the brain, is a hallmark of Alzheimer's that begins in the earliest stages of the disease — even before an individual experiences visible symptoms of dementia.

With the introduction of benzodiazepines such as chlordiazepoxide (Librium) and diazepam (Valium) in the early 1960s, a new era in the treatment of insomnia and anxiety began. The benzodiazepines were more effective and far safer than the older drugs — barbiturates, meprobamate, and glutethimide — that had been prescribed for these purposes. For many years, benzodiazepines continued to be the most popular prescription tranquilizers and sedatives. Since the mid-1980s, new alternatives have been assuming some of these roles, but benzodiazepines are not about to leave the stage.

More than a dozen benzodiazepines are available by prescription. Benzodiazepines have a common basic chemical structure, and they all increase activity at receptors for the neurotransmitter gamma-aminobutyric acid (GABA). This transmitter inhibits the activity of neurons, slowing down the brain and nervous system. Benzodiazepines differ mainly in how quickly they are absorbed, how long their effects last, and how long they take to leave the body.

It’s well known that getting enough sleep is critical to daily functioning and long-term health. Now, new research suggests that a lack of enough REM sleep may be related to earlier death in people at middle age or older.