Cholesterol Archive

Two medications now in development, enlicitide and obicetrapib, can lower harmful LDL cholesterol and may be promising options for people who cannot tolerate statins or who still have high LDL despite their current treatment.

ApoB is a protein that attaches to harmful fat particles in the blood to form lipoproteins, including low-density lipoprotein (LDL). An apolipoprotein B (apoB) test counts the number of LDL particles in the bloodstream as well as other particles that can contribute to clogged arteries and heart attacks.

A 2025 study suggests that polyphenols, found in a wide range of plant foods, may have long-term benefits for the heart. Over an average of 11 years, people whose diets contained the most polyphenol-rich foods ranked lowest on scores of heart disease risk.

A one-time infusion of a gene-editing therapy called CTX310 may safely lower cholesterol and triglyceride levels, according to a small preliminary trial. The first-in-human study, published in 2025, included 15 people with uncontrolled LDL cholesterol, triglycerides, or both.

For stroke survivors, reaching a very low LDL (bad) cholesterol level may reduce their risk of future strokes and other cardiovascular problems, according to a 2025 study.

Social media posts tend to exaggerate side effects (such as muscle aches and memory problems) associated with statins and may spread invalid information about these drugs. This misinformation is a major threat to public health, according to a 2025 article.

Reclining and lying down may be linked to worse cardiovascular health while short bouts of sitting or standing may reduce cardiovascular risk, according to a 2025 study.

In a 2025 study, skipping breakfast was associated with a 10% increased risk for metabolic syndrome, a disorder defined by having three or more of the following: abdominal obesity, high blood pressure, high blood sugar, high triglycerides, and low HDL cholesterol.

An apolipoprotein B (apoB) test counts the number of LDL particles in the bloodstream as well as other particles that can contribute to clogged arteries and heart attacks. All of these so-called atherogenic particles carry a single apoB molecule but varying amounts of cholesterol. ApoB values are more closely linked to heart disease risk than LDL cholesterol. People with signs of an unhealthy metabolism—such as prediabetes, a big belly, or elevated triglycerides—are far more likely to have a high apoB.

Eating a variety of flavonoid-rich foods may offer greater protection against cardiovascular disease and cancer than eating only a few high-flavonoid foods, according to a 2025 study.