Alzheimer's Archive

It has been known for some time that air pollution causes heart and lung diseases. Now, results from three different studies on populations in different parts of the world show an association between higher levels of air pollution and greater risk of cognitive impairment, dementia, and Alzheimer’s disease.

An analysis of multiple studies looking at the relationship between high blood pressure and cognitive health –– abilities like thinking, memory, and attention –– found that older people who lower high blood pressure are slightly less likely to develop cognitive impairment or dementia.

Research we're watching

Could a single blood test one day enable doctors to diagnose Alzheimer's disease? Researchers writing in the March 2 issue of Nature Medicine say they've made advances in this area. The blood test they developed measures the concentration of pTau181 — a form of the tau protein associated with brain changes in Alzheimer's disease — in the body's blood plasma. They used the test on samples collected from more than 400 people who were part of an ongoing -memory study.

The researchers found that the blood test was able to accurately detect which patients had Alzheimer's, which were healthy, and which had a different type of dementia caused by a neurodegenerative disease. Today, doctors typically diagnose Alzheimer's using a series of tests designed to rule out other causes, but the process is time-consuming and costly. The researchers are now aiming to refine the test further, in hopes that it will someday make it easier to detect Alzheimer's at an early stage, when the disease may be easier to treat.

As more older people undergo surgeries, the risk of complications increases, including for cognitive decline following their procedures, particularly after cardiac surgery. But awareness and pre-planning with your care team can help you avoid such complications.

If you or someone else suspects early signs of memory loss, here's how you can find out if there's a problem.

There's no cure for dementia, and you cannot substantially reverse its effects, but there are ways to possibly slow its progression. But first, you need to know if you — or a loved one — may have a memory disorder. "Unfortunately, there is not one single test that confirms dementia while you are alive," says Dr. Julie Brody Magid, clinical director of the Harvard-affiliated McLean Hospital Memory Disorders Assessment Clinic. "The testing process is multilayered and takes many things into consideration. Going through this evaluation may help identify memory problems before they get worse."

Know the symptoms

Symptoms of dementia include memory loss, problem-solving difficulties, and language issues. Behavior and emotions also can be affected. Symptoms are often subtle early on, and then get progressively worse. They can increasingly interfere with daily life tasks, like remembering to attend appointments, take medication, or pay bills. People also may have trouble preparing meals or driving safely.

The conditions imposed by the COVID-19 pandemic are challenging for all of us, but are especially difficult for teenagers with autism spectrum disorder and their families. Strategies to support teens and families living with ASD can help lessen the impact of the virus.

In the journals

Older adults with a healthy weight but a large waistline could have a higher risk of developing dementia, according to a recent study.

Weight gain and obesity are known risk factors for dementia, and body mass index (BMI) is often used to estimate excess body fat. (BMI is a measure that takes into account both weight and height.)

For young people with autism spectrum disorder, the transition from adolescence to adulthood is marked by changes in many areas of their lives. Healthcare providers and caregivers can make this transition smoother and help their patients meet these challenges.

There is evidence that antidepressants are not effective in older people with dementia. Emerging research suggests that nondrug, psychosocial interventions are the most effective treatments for depression or anxiety in older adults with cognitive impairment.

In older people, the majority of falls occur when someone is standing or walking while also performing a separate cognitive or motor task. These tasks require more cognitive effort as we age, but focus and awareness can prevent falls from happening.