Why might your GGT (gamma-glutamyl transferase) level be elevated?
Ask the doctor
Q. My lab test results showed high gamma-glutamyl transpeptidase levels. I do not consume alcohol, nor am I taking any medications. Is this a concern? What are my next steps?
A. Gamma-glutamyl transpeptidase (GGT) is an enzyme made in the liver. Some is released into the bloodstream. Higher than normal blood levels of GGT may indicate recent alcohol use or a liver problem. Also, many medications can cause a high GGT on a blood test.
Even though you don't take any prescription drugs, you might be taking an over-the-counter drug, herb, or supplement that is causing the elevated GGT. Examples include:
- acetaminophen (Tylenol and generic versions, alone or part of combination pain relief and cold remedies)
- ibuprofen (Advil, Motrin, generics)
- naproxen (Aleve, generics)
- vitamin A in high doses.
Many herbal products have been reported to cause an abnormal GGT. Kava and black cohosh have been associated with liver injury.
Two relatively common liver conditions that could cause an elevated GGT are fatty liver (metabolic dysfunction-associated steatotic liver disease, or MASLD) and hepatitis C infection. Very often there are no symptoms with these conditions.
Life and health insurance companies often run a GGT test on blood taken as part of a qualifying exam.
Talk to your doctor. Your doctor will likely order additional blood tests that will give you a better picture of whether there is an underlying liver problem.
Image: © bymuratdeniz/Getty Images
About the Author
Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing
Disclaimer:
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
