Intermittent fasting: Does a new study show downsides — or not?

Intermittent fasting (IF) is an approach to eating based on timing. The idea is that fasting for long enough allows insulin levels to fall low enough that our body will use fat for fuel. Growing evidence in animals and humans shows that this approach leads to significant weight loss. When combined with a nutritious, plant-based diet and regular physical activity, IF can be part of a healthy weight loss or maintenance plan, as I described in an earlier blog post.

Now, a randomized controlled trial published in JAMA claims that IF has no significant weight loss benefit and a substantial negative effect on muscle mass. News outlets picked up the story and ran headlines like A Potential Downside of Intermittent Fasting and An Unintended Side Effect of Intermittent Fasting.

But what did this study actually look at and find?

In the study, 141 patients were randomly assigned to 12 weeks of either a time-restricted eating plan (TRE) that involved fasting for 16 hours and eating only during an eight-hour window of the day, or a consistent meal timing (CMT) eating plan, with three structured meals a day plus snacks.

Neither group received any nutrition education or behavioral counseling, nor was physical activity recommended. There was no true control group (meaning a group that did not receive any instructions about meal timing).

Interestingly, both groups lost weight. Given the headlines, I had to read and reread the results several times, because they show that the IF group lost a statistically significant amount of weight from beginning to end — which wasn’t true in the CMT group. The researchers reported: “There was a significant decrease in weight in the TRE group (−0.94 kg; 95% CI, −1.68 kg to −0.20 kg; P = .01) and a nonsignificant decrease in weight in the CMT group (−0.68 kg; 95% CI, −1.41 kg to 0.05 kg; P = .07).”

Translated into plain English, the IF group lost more weight than could be due to chance: between half a pound and 4 pounds, or an average of 2 pounds. The structured meals group also lost some weight, although the amounts lost could have been due to chance: between 0.1 and 3 pounds, or an average of 1.5 pounds. The upshot was that there wasn’t a significant difference in weight change between the two groups. And the researchers saw a loss of muscle mass in the IF group that didn’t occur in the CMT group.

Diving deeper into the study

By the way, all of these folks may have been eating fried or fast foods, and sugary sodas and candy — we don’t know. The study doesn’t mention quality of diet or physical activity. This isn’t how IF is supposed to be done! And yet the IF folks still lost between half a pound and 4 pounds.

Importantly, the structured meals group also lost weight. While not significant enough to prove it was due to this intervention, for some participants it was enough to make structured meal weight loss differ little from IF weight loss. But think about it: structured meals are an intervention. After all, some people eat more than three times a day, consuming multiple small meals throughout the day. Telling people to limit their eating to three mealtimes plus snacks may actually be helping some to eat less.

The authors very well could have concluded that IF was indeed successful. They might also call for a follow-up study with a true no-intervention control group, as well as behavioral counseling, guidance on a healthy diet, and recommended activity levels for IF and CMT groups.

Does additional support make a difference?

Prior studies of IF that have provided behavioral counseling, and guidance on nutrition and activity, have definitely shown positive results. For example, in a previous blog post I described a 2020 American Journal of Clinical Nutrition study in which 250 overweight or obese adults followed one of three diets for 12 months:

  • IF on the 5:2 protocol, which means drastically reducing food intake for any two of five days of the week (down to 500 calories for women and 700 calories for men)
  • Mediterranean, which emphasized fruits and vegetables, legumes, nuts, seeds, whole grains, and olive oil with moderate fish, chicken, eggs, and dairy, and with an allowance of one glass of wine per day for women and two per day for men
  • Paleo, which emphasized fruits and vegetables, animal proteins, coconut products, butter, and olive oil, along with some nuts, seeds, and legumes.
  • And this is key: all participants were provided education on behavioral strategies for weight loss, stress management, sleep, and exercise.

Everyone lost weight. The IF group lost more than anyone with an average of 8.8 pounds, Mediterranean next at 6.2 pounds, and Paleo last at 4 pounds. Adherence was better with the Mediterranean diet (57%) and IF (54%) than with the Paleo diet (35%), and better adherence resulted in one to three pounds more weight loss. The Mediterranean and IF groups also saw significant drops in blood pressure, another good result.

What about the loss in muscle mass that occurred in the IF group in the JAMA study? While this needs to be studied further, it’s important to note that other research on IF that included guidance on physical activity did not show any loss of muscle mass.

The bottom line

What’s the takeaway here? A high-quality diet and plenty of physical activity — including resistance training — are critical for our good health, and nothing replaces these recommendations. IF is merely a tool, an approach that can be quite effective for weight loss for some folks. While this one negative study adds to the body of literature on IF, it doesn’t reverse it. We simply need more high-quality studies in order to have a better understanding of how to most effectively incorporate IF into a healthy lifestyle.


  1. GN

    Thank you for writing this. When I saw the headlines from the original report, I stopped my IF routine, which consists of fasting 16 hours (water/1 black coffee) a day. I do this five times a week. From February through August I lost 14 pounds, with moderate exercise 3-4 times a week. But then I saw this new report and stopped a month or so ago. Needless to say, I gained a few pounds back since I stopped my IF. If anything, IF helps restrict when I can and cannot eat. So even if IF has no significant impact on metabolic rate, it structures my eating so I don’t eat late at night or a second dinner! I’m hopping back on the IF train.

    • Adenan

      Fantastic. Return to IF , I support U . Me n family on it for 14 months on going . Includes the 3 MD ‘s in d family .
      For avoiding muscle loss try lightweights rituals.
      Dr. Adenan

  2. Suzanne Ralich

    Thanks for your article! I need more info on how to avoid muscle loss during IF. I love how I feel doing IF but work out hard but dont eat until 11am. Hard to change my 11 to 6pm times.

  3. cheivee8ai

    Started doing this a week and a half ago and already feel great. Haven’t weighed in yet, but clothes are getting looser. It’s more than that, though. I have a LOT more energy and I feel like my brain works again. One thing she didn’t mention is that you will feel hungry. In the first few days that is the HARDEST part. Especially if you’re used to eating when you’re hungry. This takes the most will power. But after a few days to a week, it gets easier. You get used to feeling hungry and it often goes away as well. You have to let yourself get used to that feeling and know that you won’t die from it.

    • Jacob Werdin

      Most times when you feel hunger pangs you’re also just dehydrated so try more water too. I’ve been doing IF for a year and it’s changed my whole life for the better for sure.

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