Drug interactions Archive

Toenail fungus, ingrown toenails, and brittle or cracked fingernails are common nail problems that affect older adults. They can make hands and feet unsightly and sometimes even painful. Treating these problems and preventing them from returning often takes a trial-and-error approach, diligence, and patience. Strategies include a combination of home remedies, over-the-counter medication, and good hygiene and grooming habits.

As people get older, they may get clumsier because of multiple factors such as declining hearing and vision, loss of muscle, balance issues, and chronic health conditions. Addressing these issues can help people avoid injury from falls and other accidents.

An inexpensive blood test that checks for a genetic variant of Lp(a)-a fatty particle similar to LDL cholesterol-may help clarify who might benefit from a daily low-dose aspirin, according to a 2025 review of study findings.

A 2025 analysis found that tricyclic antidepressants, the anticonvulsants gabapentin (Neurontin) and pregabalin (Lyrica), and serotonin-norepinephrine reuptake inhibitors, such as duloxetine (Cymbalta) were the most effective drug treatments for neuropathic pain.

There are currently nine trials of vaccines for Alzheimer's disease under way. All of them are in people with mild Alzheimer's or with the pre-Alzheimer's condition called mild cognitive impairment. All of the vaccines are designed to encourage the immune system to remove protein deposits from the brain. Most experimental vaccines are given by injection; one being tested at Harvard Medical School uses a nasal spray. It will be several years before we know if any of them will work.

Semaglutide, a GLP-1 agonist used to treat diabetes and obesity, may also help people with metabolic dysfunction-associated steatohepatitis, a severe stage of fatty liver disease, suggests a 2025 study.

While many health symptoms resolve quickly on their own, others linger and make people wonder if they need to see a doctor. Symptoms that warrant a doctor's visit include drawn-out cold symptoms such as fatigue, cough, and low-grade fever; a fever lasting more than four days; unexpected symptoms when starting a new medication or after surgery; certain digestive problems; and new or worsening mental health issues.

The four types of anesthesia include local anesthesia, regional anesthesia, monitored anesthesia, and general anesthesia. Before getting anesthesia, one should ask the doctor which type of anesthesia will be administered, what its risks are, and if delirium is a high risk. One should also ask how to prepare for anesthesia in the days leading up to a procedure-whether medications might need to be temporarily halted, when to stop eating or drinking before surgery, and whether to schedule measures to help reduce delirium.

A 2025 randomized controlled trial found that GLP-1 receptor agonists, the blockbuster drugs approved to treat diabetes and obesity, boosted the walking ability of people with diabetes and peripheral artery disease (PAD) in the legs. The news is encouraging, since there are few effective treatments for PAD-reduced blood flow in the limbs that leads to pain with activity. However, it will take more evidence before doctors feel comfortable prescribing GLP-1s if a person only has PAD.