Circulatory System Archive

Edema is swelling caused by fluid trapped in body tissues. It can occur in anyone, but it’s more common in older adults. A variety of factors contribute to mild edema, including weakened valves in veins, gravity, inactivity, arthritis, and certain medications.

Compression socks are snug, supportive stockings that can help people who struggle with leg swelling or circulation issues. They’re commonly used for certain vein problems or clot risks, and a doctor can help decide who needs them and how to use them.

Several conditions can cause people to feel cold when others are comfortable. These include low body weight, an underactive thyroid, low red blood cell count (anemia), and Raynaud’s phenomenon.

Venous insufficiency can cause swelling in the lower legs and feet, a sense of heaviness in the legs, and in some cases, skin discoloration. Treatments include elevating the legs, walking, and wearing compression stockings.

A 2025 randomized controlled trial found that GLP-1 receptor agonists, the blockbuster drugs approved to treat diabetes and obesity, boosted the walking ability of people with diabetes and peripheral artery disease (PAD) in the legs. The news is encouraging, since there are few effective treatments for PAD—reduced blood flow in the limbs that leads to pain with activity. However, it will take more evidence before doctors feel comfortable prescribing GLP-1s if a person only has PAD.

Fatty plaque that accumulates in the arteries of the legs, known as peripheral artery disease (PAD), can cause a painful, crampy sensation in the legs during walking. Smoking, obesity, diabetes, high blood pressure, and elevated cholesterol increase the risk of PAD, which affects nearly one in three people over age 75. Beyond quitting smoking, regular walking is the best treatment for PAD. A 2025 study found that semaglutide (Ozempic, Wegovy) may help people with PAD walk farther with less pain.

People with very high calcium scores (over 1,000) have a risk of heart attack or stroke similar to those who have already had a heart attack. They should take cholesterol-lowering drugs to bring down LDL levels and possibly undergo additional testing.